Results 91 to 100 of about 33,517,941 (337)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Technical approbation of the method for testing on vibration effects of on-board radio-electronic equipment of spacecrafts [PDF]

Космические аппараты и технологии
The article provides a description of the developed method, which ensures the correct realization of mechanical tests of on-board radio-electronic equipment of spacecrafts for vibration effects in the process of ground experimental testing.
A. А. Khvalko, A. S. Orlov, S. B. Suntsov, I. S. Vasiliev, A. A. Goryainova   +4 more
doaj  

Identifying Optimal Baseline Variant of Unsupervised Term Weighting in Question Classification Based on Bloom Taxonomy

Mendel, 2022
Examination is one of the common ways to evaluate the students’ cognitive levels in higher education institutions. Exam questions are labeled manually by educators in accordance with Bloom’s taxonomy cognitive domain. To ease the burden of the educators,
Anbuselvan Sangodiah, Tham Jee San, Yong Tien Fui, Lim Ean Heng, Ramesh Kumar Ayyasamy, Norazira A Jalil   +5 more
doaj  

Technical Information Systems [PDF]

, 1958

openalex   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Dynamic storage allocation for an information retrieval system [PDF]

, 1961
Burnett H. Sams
openalex   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Developing a Reference for Smart Rural Communities: An Enterprise Architecture Perspective for Smart Governance

Jurnal Sistem Informasi
The digital transformation of rural governance is critical to achieving Sustainable Development Goals (SDGs) and fostering community self-reliance.
Intania Fadya Safitri, Asti Amalia Nur Fajrillah, Iqbal Yulizar Mukti   +2 more
doaj   +1 more source