Results 111 to 120 of about 36,992,088 (301)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Computer based distribution information system
, 2011 In this abstract part I have to explain the goals and purpose of my project, title as DISTRIBUTION INFORMATION SYSTEM. The main purpose of my project is to develop a computerized system for maruthamunai janet distribution system. So, I have to develop
Shimala, H
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Protecting information in systems of systems
, 2011 Systems of Systems (SoS) are dynamic, distributed coalitions of autonomous and heterogeneous systems that collaborate to achieve a common goal. While o¿ering several advantages in terms of scalability and ¿exibility, the SoS paradigm has a strong impact on system interoperability and on the security requirements of collaborating parties.
Trivellato, Daniel +2 more
openaire +2 more sources
Impact of Mobility on Information Systems and Information System Design
, 2004 The subject of this thesis is to analyse the impact of mobile hardware and software on information systems, to survey existing approaches for specifying mobile systems of computer science in general, and to provide suitable means for the formal design of information systems comprising such mobile units in particular. We consider a mobile unit to denote
openaire +3 more sources
gCube Information System Model
, 2019 Information System Model Documentation Documentation is available on-line in the gCube Wiki: https://wiki.gcube-system.org/gcube/index.php/Facet_Based_Resource_Model Installation Installation documentation is available on-line in the gCube Wiki:
Luca Frosini, Luca Frosini (5206879)
core +1 more source