Results 101 to 110 of about 36,992,088 (301)

Information Systems and Sign Systems

, 2015
The organisational world can be considered as a collective of social sign systems and formal sign systems (computer based information systems). In this paper the issue of the fundamental differences between the two kinds of sign systems will be discussed, and the implications of these fundamental differences for system development.
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Technical approbation of the method for testing on vibration effects of on-board radio-electronic equipment of spacecrafts [PDF]

Космические аппараты и технологии
The article provides a description of the developed method, which ensures the correct realization of mechanical tests of on-board radio-electronic equipment of spacecrafts for vibration effects in the process of ground experimental testing.
A. А. Khvalko, A. S. Orlov, S. B. Suntsov, I. S. Vasiliev, A. A. Goryainova   +4 more
doaj  

Web-Based Internship Information System Using Geolocation and Geofencing in the Information Systems Department of Muria Kudus University

Jurnal Sistem Informasi
Internship administration at Universitas Muria Kudus remains constrained by manual attendance records, physical logbooks, limited progress monitoring, and the absence of location-based validation. This study developed and evaluated a web-based internship
Auliya Firdausiyah, Fajar Nugraha, Supriyono Supriyono   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

GIWIS: Geospatial Workforce Information System

The Geospatial Workforce Information System (GIWIS) provides resources to serve job seekers, employers, students, and connects people with each other and with information, data, and jobs in the geospatial industry.

core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Work System Method for Understanding Information Systems and Information Systems Research

Communications of the Association for Information Systems, 2002
The work system method is a broadly applicable set of ideas that use the concept of “work system” as the focal point for understanding, analyzing, and improving systems in organizations, whether or not IT is involved. The premises underlying this method may be controversial in the IS community because they imply that the traditional jargon and concerns
openaire   +3 more sources