Results 91 to 100 of about 32,892,195 (295)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Information Systems and Sign Systems
, 2015 The organisational world can be considered as a collective of social sign systems and formal sign systems (computer based information systems). In this paper the issue of the fundamental differences between the two kinds of sign systems will be discussed, and the implications of these fundamental differences for system development.
openaire +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Other title: Retirement Benefit Information for Kansas Employers
, 2004 application/pdfA set of 10 documents provided by the Kansas Public Employees Retirement System with Retirement Benefit Information for Kansas Employers.Welcome to the Team: for New Designated Agents (August 2004) Welcome to the Team: for New Designated ...
Kansas Public Employees Retirement System.
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Technical approbation of the method for testing on vibration effects of on-board radio-electronic equipment of spacecrafts [PDF]
Космические аппараты и технологииThe article provides a description of the developed method, which ensures the correct realization of mechanical tests of on-board radio-electronic equipment of spacecrafts for vibration effects in the process of ground experimental testing.
A. А. Khvalko +4 more
doaj
Jurnal Sistem InformasiInternship administration at Universitas Muria Kudus remains constrained by manual attendance records, physical logbooks, limited progress monitoring, and the absence of location-based validation. This study developed and evaluated a web-based internship
Auliya Firdausiyah +2 more
doaj +1 more source
, 2018 Information ...
Office of the System Chief Information Officer, Information Technology Security and Policy
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