Results 71 to 80 of about 1,715,165 (266)

A Novel Group Decision Making Method Under Uncertain Multiplicative Linguistic Environment for Information System Selection

open access: yesIEEE Access, 2019
An effective method is proposed to solve the group decision-making problems with uncertain multiplicative linguistic information. First, to compare two uncertain multiplicative linguistic variables, a possibility degree formula is introduced in ...
Jian Lin, Riqing Chen
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Optimized Design of Distributed Generalized Reed-Solomon Coded Generalized Spatial Modulation [PDF]

open access: yesRadioengineering
To meet the need of modern society for more reliable and efficient communications, this paper applies the generalized spatial modulation (GSM) technique in the distributed generalized Reed-Solomon (GRS) coding to propose a novel distributed GRS coded GSM
C. L. Zhao, F. F. Yang, H. J. Xu
doaj  

CAN THE INTERNAL CONTROL SYSTEM REDUCE FRAUDULENT USE OF VILLAGE FUNDS IN ADVERSE SELECTION CONDITION?

open access: yesJurnal Tata Kelola dan Akuntabilitas Keuangan Negara, 2019
In recent years, corruption cases at the village level have been in the public spotlight. This was evidenced through around 154 corruption cases at the village level involving 112 village heads, 32 village officials and 3 village heads.
Theresia Febiengry Sitanala
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Information Security Role Model for Staff of Banking Structures

open access: yesБезопасность информационных технологий, 2012
Categories roles of information security employees of the banking organization are defined. Functional roles are described. The relationship between functional roles, employees, functions and authority are defined.
A. O. Vybornov   +2 more
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Improved Bayesian Best-Worst Networks With Geographic Information System for Electric Vehicle Charging Station Selection

open access: yesIEEE Access
Electric vehicle charging stations (EVCSs) are essential for solving the energy consumption and endurance anxiety problems of car owners. EVCSs also promote sustainable development in urban economies without relying on fossil fuels.
Xiaojia Wang   +3 more
doaj   +1 more source

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