Results 101 to 110 of about 43,078,898 (347)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Automated Skin Cancer Classification Using VGG16-Based Deep Learning Model [PDF]

open access: yesE3S Web of Conferences
Melanoma is the most fatal type of skin cancer due to its high potential to metastasize and its early-stage similarity to benign skin lesions, such as common moles. This resemblance often leads to delayed diagnosis and treatment.
Cinthya Monica   +7 more
doaj   +1 more source

Knowledge and information systems

open access: yes, 2018
Knowledge and Information Systems (KAIS) provides an international forum for researchers and professionals to share their knowledge and report new advances on all topics related to knowledge systems and advanced information systems.
E. Šilerová, L. Kučírková
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Sparse Array Design Based on the Combination of Improved Binary Grey Wolf Optimisation and Genetic Algorithm

open access: yesIET Radar, Sonar & Navigation
Traditional adaptive beamforming techniques focus solely on optimising the excitation weights of array elements while neglecting the critical influence of element positioning on beamforming performance.
Weinian Li   +4 more
doaj   +1 more source

In-Vehicle Information Systems

open access: yesPromet (Zagreb), 2012
The work considers different information systems, includingthe infonnation ~ystems with autonomous units, whichcany all their intelligence around with them, and those withcommunicating units, which infonn the motorist about the currentsituation of the ...
Gordana Štefančić   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

In-Vehicle Information Systems

open access: yesPromet (Zagreb), 2002
The paper considers different systems, including thesystems with autonomous units, which cany all their knowledgewith them, and those with communication units, which informthe driver about the current situation of the road system byradio or other means ...
Gordana Štefančić   +2 more
doaj   +1 more source

Design of Information Systems and Computer Sales Computer Accessories Assembly in. Billy Moon Using Visual Foxpro 9.0 [PDF]

open access: yes, 2010
Sales of Computer Information Systems and Computer Assembled Accecories, is onevery important part in a company, particularly those engaged in trade. Because inactivities jualbeli transaction.
Elly Agustina J.,S.Kom.,MMSI   +1 more
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