Results 121 to 130 of about 4,020,268 (318)

A systematic review of machine learning algorithms for mortality risk, readmission and phenotype prediction in patients with heart failure: exploring key data sources, input variables and outcomes

BMC Medical Informatics and Decision Making
Background Heart failure is not only a prevalent disease with a high mortality rate, but also generates high costs for healthcare systems. By training artificial intelligence (AI) models on medical data, it is possible to predict changes in health status
Aleksandra Flok, Patricia Kajüter Rodrigues, Sofiya Pohurskyy, Frank Teuteberg   +3 more
doaj   +1 more source

Dynamic process modelling for business engineering and information systems evaluation

, 1999
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This research is concerned with the pre-implementation evaluation of investments in Information Systems (IS).
Giaglis, George M
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Scaling up repowering decisions: a farm-level financial decision support system for onshore wind energy assets

Energy Informatics
The aging of wind energy assets and the expiration of government subsidies make decisions on continued operation, repowering, and decommissioning increasingly critical for wind farm operators.
Yifan Wang, Maximilian Heumann, Tobias Kraschewski, Michael H. Breitner   +3 more
doaj   +1 more source

A Design Theory for Secure Information Systems Design Methods

, 2006
Many alternative methods for designing secure information systems (SIS) have been proposed to ensure system security. However, within all the literature on SIS methods, there exists little theoretically grounded work that addresses the fundamental ...
Heikka, Juhani, Siponen, Mikko, Baskerville, Richard   +2 more
core   +1 more source

Value Sensitive Analysis of the Persuasion Context : Case Micro-entrepreneurs’ Health Promotion [PDF]

, 2020
Even though the definition of persuasive systems rules out using coercion or deception, in practice it is a challenge to design ethically sound information systems, especially when the use context deals with personal matters such as one’s health or ...
Muhos, Matti, Kuonanoja, Liisa, Oinas-Kukkonen, Harri   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Assessing the Maturity Level of Open Ticket Services Using ITIL V4 Framework

Journal of Applied Informatics and Computing
Information technology services are fundamental in facilitating academic operations within higher education institutions. One essential component of IT service delivery is a ticket-based system designed to manage user-reported incidents and service ...
Arvhi Randita Setia, Allsela Meiriza, Hardini Novianti   +2 more
doaj   +1 more source

Information Systems [PDF]

Yearbook of Medical Informatics, 1994
openaire   +2 more sources