Results 131 to 140 of about 4,635,546 (299)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Information Extraction from Multi-Domain Scientific Documents: Methods and Insights
Applied SciencesThe rapid growth of scientific literature necessitates effective information extraction. However, existing methods face significant challenges, particularly when applied to multi-domain documents and low-resource languages.
Tatiana Batura +5 more
doaj +1 more source
Patterns of health information exchange strategies underlying health information technologies capabilities building. [PDF]
Health Syst (Basingstoke), 2022 Poba-Nzaou P +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
On the Impact of Information Technologies Secondary-School Capacity in Business Development: Evidence From Smart Cities Around the World. [PDF]
Front Psychol, 2021 Barba-Sánchez V +2 more
europepmc +1 more source
INFORMATION AND THE ADOPTION OF PRECISION FARMING TECHNOLOGIES [PDF]
Precision farming technologies have been commercially available since the early 1990s, but the pace of adoption among U.S. farmers has been modest. This study examines the relationship between the adoption of diagnostic and application techniques of ...
Daberkow, Stan G., McBride, William D.
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Sub-optimal knowledge with positive attitude and belief of frontline health workers toward the use of information technologies: A mixed-method study from rural Haryana, India. [PDF]
J Educ Health Promot, 2022 Sathiyamoorthy R +7 more
europepmc +1 more source