Results 131 to 140 of about 4,612,999 (280)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Patterns of health information exchange strategies underlying health information technologies capabilities building. [PDF]
Health Syst (Basingstoke), 2022 Poba-Nzaou P +4 more
europepmc +1 more source
INFORMATION AND THE ADOPTION OF PRECISION FARMING TECHNOLOGIES [PDF]
Precision farming technologies have been commercially available since the early 1990s, but the pace of adoption among U.S. farmers has been modest. This study examines the relationship between the adoption of diagnostic and application techniques of ...
Daberkow, Stan G., McBride, William D.
core +1 more source
Information Security & Privacy Office [PDF]
, 2018 Information, from their website, on the Information Security & Privacy Office. This office is located with Information Technologies and deals with the privacy and ethical management of data at the ...
Information Technologies
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Sub-optimal knowledge with positive attitude and belief of frontline health workers toward the use of information technologies: A mixed-method study from rural Haryana, India. [PDF]
J Educ Health Promot, 2022 Sathiyamoorthy R +7 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
On the Impact of Information Technologies Secondary-School Capacity in Business Development: Evidence From Smart Cities Around the World. [PDF]
Front Psychol, 2021 Barba-Sánchez V +2 more
europepmc +1 more source