Results 131 to 140 of about 21,736,361 (314)

Application of Blockchain Technologies and Smart Contracts for the Storage and Verification of Academic Transcripts in the Higher Education Systems

Information
This article discusses the practical implementation of a prototype academic transcript storage system based on blockchain technology and smart contracts.
Olga Ussatova, Vladislav Karyukin, Yenlik Begimbayeva, Galimkair Mutanov, Yerlan Kistaubayev, Medet Turdaliyev   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Minutes: Senate Committee on Information Technologies: September 10, 2018

, 2018
University of Minnesota: Senate Committee on Information Technologies. (2018). Minutes: Senate Committee on Information Technologies: September 10, 2018.
University of Minnesota: Senate Committee on Information Technologies
core  

Privacy Practices of Health Information Technologies: Privacy Policy Risk Assessment Study and Proposed Guidelines. [PDF]

J Med Internet Res, 2021
LaMonica HM, Roberts AE, Lee GY, Davenport TA, Hickie IB.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Minutes: Senate Committee on Information Technologies: October 6, 2015

, 2015
University of Minnesota: Senate Committee on Information Technologies. (2015). Minutes: Senate Committee on Information Technologies: October 6, 2015.
University of Minnesota: Senate Committee on Information Technologies
core  

Patterns of health information exchange strategies underlying health information technologies capabilities building. [PDF]

Health Syst (Basingstoke), 2022
Poba-Nzaou P, Uwizeyemungu S, Dakouo M, Tchibozo A, Mboup B.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Minutes: Senate Committee on Information Technologies: April 3, 2018

, 2018
University of Minnesota: Senate Committee on Information Technologies. (2018). Minutes: Senate Committee on Information Technologies: April 3, 2018.
University of Minnesota: Senate Committee on Information Technologies
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source