Results 71 to 80 of about 107,894 (308)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Research on the Configuration Path of Digital-Intelligent Enabled Urban Rainstorm Situation Awareness in Ternary Space

Redai dili
Against the backdrop of rapid urbanization and escalating risks posed by extreme rainstorms, the complexity of urban hydrological systems and limitations of fragmented data-driven approaches underscore the necessity of constructing integrated frameworks ...
Yan Xuxian, Wang Junli, Wen Xuan, Liu Yang   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Editorial Special Issue on Enhancement Algorithms, Methodologies and Technology for Spectral Sensing [PDF]

, 2010
The paper is an editorial issue on enhancement algorithms, methodologies and technology for spectral sensing and serves as a valuable and useful reference for researchers and technologists interested in the evolving state-of-the-art and/or the emerging ...
Gillespie, Patti, Gupta, Neelam, Hayat, Majeed M., Jensen, James O., Li, Yanqiu, Theriault, Jean-Marc, Trew, Robert J., Woolard, Dwight L.   +7 more
core   +1 more source

Some stylized facts of the Bitcoin market [PDF]

, 2017
In recent years a new type of tradable assets appeared, generically known as cryptocurrencies. Among them, the most widespread is Bitcoin. Given its novelty, this paper investigates some statistical properties of the Bitcoin market.
Basgall, María José, Fernández, Aurelio, Hasperué, Waldo, Naiouf, Ricardo Marcelo   +3 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Joint safety and security risk analysis in industrial cyber‐physical systems: A survey

IET Cyber-Physical Systems
Industrial Cyber‐Physical Systems (iCPSs) represent a new generation of industrial systems that enable a profound integration of industrial processes and informational spaces, thereby empowering the fourth industrial revolution.
Zhicong Sun, Guang Chen, Yulong Ding, Shuang‐Hua Yang   +3 more
doaj   +1 more source

A qualitative study investigating users’ perspective of bariatric surgery online health communities in facilitating social support

Australian Journal of Psychology
Objective To fulfil a need for greater access to social support postoperatively, adults who have undergone bariatric surgery have turned to Online Health Communities (OHCs).
Charlene Wright, Danielle Dawson, Joy Parkinson, Kyra Hamilton   +3 more
doaj   +1 more source

Buyer-supplier partnership in agile supply chains: A conceptual view [PDF]

, 2010
The purpose of this paper focuses on achieving agility within the supply chain and seeks to examine the impact of developing an integrated buyer-supplier partnership on achieving agility.
El-Tawy, Nesrine, Gallear, D
core