Advanced Science, EarlyView.Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao +25 more
wiley +1 more source
[Technical cooperation strategies to revitalize immunization programs in priority countries in the AmericasEstratégias de cooperação técnica para revitalização do programa de imunização em países prioritários da Região das Américas]. [PDF]
Rev Panam Salud PublicaPastor D +4 more
europepmc +1 more source
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
[Lessons learned in the implementation of measles and rubella vaccination campaigns in the AmericasLições aprendidas com a implementação de campanhas de vacinação contra sarampo e rubéola na Região das Américas]. [PDF]
Rev Panam Salud PublicaDurón R +3 more
europepmc +1 more source
Tablero de control negociaciones nacionales Constructora Bolívar
Este documento tiene como propósito, presentar el avance sobre el proyecto de desarrollo del tablero de control de negociaciones nacionales para Constructora Bolívar en donde se abordará los pasos implementados de la metodología planteada para el ...
Sanabria Uribe, Juan Manuel
core
Advanced Science, EarlyView.Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman +11 more
wiley +1 more source
[Substandard and falsified medical products: 25 years of successful network collaboration among regulatory authorities in the AmericasProdutos médicos de qualidade inferior e falsificados: 25 anos de colaboração bem-sucedida em rede entre autoridades reguladoras da Região das Américas]. [PDF]
Rev Panam Salud PublicaVahos Zambrano J +9 more
europepmc +1 more source
Advanced Science, EarlyView.Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley +1 more source
Elimination and reemergence of measles in Mexico: historical and structural review of the 2025-2026 outbreak. [PDF]
Rev Peru Med Exp Salud PublicaMojica-López L +2 more
europepmc +1 more source
Advanced Science, EarlyView.Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong +7 more
wiley +1 more source