Results 191 to 200 of about 381,665 (287)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

[Plasmid-mediated colistin resistance in pathogenic bacteria]. [PDF]

Rev Med Inst Mex Seguro Soc
Casillas-Vega N, Mendoza-Olazarán S.
europepmc   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

[Risk factors and control measures in measles outbreaks in countries of the Region of the Americas, 2017-2023Fatores de risco e medidas de controle em surtos de sarampo em países da Região das Américas, 2017-2023]. [PDF]

Rev Panam Salud Publica
Pastor D, Bravo-Alcántara P, Durón R, Tirso CP, Ortiz C, Rey-Benito G.   +5 more
europepmc   +1 more source

EL CENTRO PARA EL ESTUDIO DE LOS PROBLEMAS NACIONALES: UN INFORME CONFIDENCIAL (COSTA RICA, 1943)

Diálogos Revista Electrónica, 2007
openaire   +4 more sources

Apreciación general de la situación de la Educación Matemática en Latinoamérica con base en los informes nacionales

, 2010
 It is done a general balance on the Mathematics Education in the Latin- American countries. Particularly, some aspects are analyzed: mathematics curriculum for primary and middle levels; pre- and in-service education of mathematics teachers; texts and didactic publications; Mathematics Education at the university; the role of mathematical associations
openaire   +1 more source

Ecosistemas acuáticos de alta montaña: refugio de biodiversidad oculta y centinelas del cambio global

Como contribuci6n a la mejora del conocimiento cientffico, a la investigaci6n en los parques nacionales y a la difusi6n de la informaci6n generada, el Organismo Aut6nomo Parques Nacionales desarrolla el Programa de Investigaci6n en la Red de Parques ...
Osorio, Víctor, Leoegw, V., Garcés-Pastor, Sandra, Pèlachs, A., Ventura, Marc, Wangensteen, Owen S., Caner, Jenny, Mendoza, Guillermo de, Pérez-Obiol, Ramón, Ninot, Josep M., Jiménez Alfaro, Borja, Pérez-Haase, A., Alonso, Miguel, Sanchez-Morales, Marc, Buchaca, Teresa, Puig, Mariàngels, Grau, O., Pladevall, E.   +17 more
core  

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

Structural Divergence Between the Moltbook AI‐Agent Network and Human Social Networks

Advanced Science, EarlyView.
Analysis of the Moltbook AI‐agent network reveals a striking combination of familiar global scaling and distinct internal organization. Attention is highly concentrated, reciprocity is limited, connected triads are suppressed, and communities are strongly modular.
Wenpin Hou, Zhicheng Ji
wiley   +1 more source

Deaf nursing professionals: experiences of social interaction and communication in professional practice. [PDF]

Rev Lat Am Enfermagem
Lima ABC, Bonini BB.
europepmc   +1 more source