Results 171 to 180 of about 461,960 (292)

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

[Social determinants, the urban environment, and public safety policies: a spatial ecological and time-series analysis of Santiago de Cali, Colombia, 2015-2024Determinantes sociais, ambiente urbano e políticas de segurança: análise ecológica espacial e de séries temporais em Santiago de Cali, Colômbia, 2015-2024]. [PDF]

Rev Panam Salud Publica
Pinzón-Flórez CE, Díaz Rivadeneira M, Escobar Morales G.   +2 more
europepmc   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

[The role of the Pan American Committee for Safe Vaccination (COPAVASE) in strengthening safe vaccination in the AmericasO papel do Comitê Pan-Americano de Vacinação Segura (COPAVASE) no fortalecimento da vacinação segura nas Américas]. [PDF]

Rev Panam Salud Publica
Gentile Á, Vergara V, Hernández H, Giraldo G, Evans-Gilbert T, Cravioto A, Teresa Valenzuela M, Figueroa P, MacDonald N, Alberto Cortés J, Felipe Molina-León H.   +10 more
europepmc   +1 more source

A Versatile DNA‐Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity

Advanced Science, EarlyView.
We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong, Sunny A. Tang, Yifan Deng, Zhihan Nan, Alison X. Gao, Gregory A. Michaud, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Shuang Liu, William J. Gibson, Stuart L. Schreiber   +11 more
wiley   +1 more source

[HEARTS quality: a policy framework to strengthen hypertension and cardiovascular risk management in primary healthcare - insights from HEARTS in the AmericasQualidade da iniciativa HEARTS: marco de políticas para fortalecer o manejo da hipertensão e do risco cardiovascular na atenção primária à saúde. Perspectivas da iniciativa HEARTS nas Américas]. [PDF]

Rev Panam Salud Publica
Londoño E, Gupta R, Van der Stuyft P, Heine M, Giraldo G, Ku GM, Brettler J, Rosende A, Irazola V, Toelsie J, Neira C, Aumala T, Valdés Y, Zúñiga E, Rodríguez L, Villatoro M, Escobar MC, Pérez V, Bencomo A, Pereira M, de la Rosa A, Ordunez P.   +21 more
europepmc   +1 more source

Ecosistemas acuáticos de alta montaña: refugio de biodiversidad oculta y centinelas del cambio global

Como contribuci6n a la mejora del conocimiento cientffico, a la investigaci6n en los parques nacionales y a la difusi6n de la informaci6n generada, el Organismo Aut6nomo Parques Nacionales desarrolla el Programa de Investigaci6n en la Red de Parques ...
Osorio, Víctor, Leoegw, V., Garcés-Pastor, Sandra, Pèlachs, A., Ventura, Marc, Wangensteen, Owen S., Caner, Jenny, Mendoza, Guillermo de, Pérez-Obiol, Ramón, Ninot, Josep M., Jiménez Alfaro, Borja, Pérez-Haase, A., Alonso, Miguel, Sanchez-Morales, Marc, Buchaca, Teresa, Puig, Mariàngels, Grau, O., Pladevall, E.   +17 more
core  

Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning

Advanced Science, EarlyView.
Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu, Frank Daniel Peters, Haokang Zhang, Madison Stiefbold, Thangam Ramar, Aditya Agarwal, Leo Q. Wan   +6 more
wiley   +1 more source

[Childhood cancer in Uruguay: A public-private partnership that delivers equity, science, and resultsCâncer infantil no Uruguai: uma parceria público-privada que promove a equidade, a ciência e os resultados]. [PDF]

Rev Panam Salud Publica
Nion G, Pagés C, Lafluf V, de Villa S, Batalla A, Silveira A, Chantada G, Castillo L.   +7 more
europepmc   +1 more source

Biodiversidad del bentos marino de parques nacionales impactados por especies invasoras y cambio climático: monitorización genética y ecológica

En esta publicación se recogen los resultados de proyectos de investigación en la Red de Parques Nacionales finalizados entre los años 2019-2023 que fueron seleccionados tras un proceso de concurrencia competitiva con una evaluación científica y técnica ...
Antich, Adrià, Zarcero, Jesús, Turon, Xavier, Marco-Méndez, Candela, Alcoverro, Teresa, Santamaría, Jorge, Ballesteros, Enric, Cebrian, Emma   +7 more
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