Results 81 to 90 of about 6,036 (219)

Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874 [PDF]

, 2015
BACKGROUND: Osteoarthritis (OA) is a painful, debilitating disease characterised by loss of articular cartilage with concurrent changes in other tissues of the synovial joint.
Andrew J. Skelton, Colin Shepherd, John Loughlin, Louise N. Reynard, Michael D. Rushton   +4 more
core   +1 more source

Single‐Nuclei Resolution of Intermuscular Adipose Tissue Indicates an Inflammation‐Associated Cellular Profile in Individuals With Knee Osteoarthritis: Findings From the SOMMA KOA Ancillary Study

Aging Cell, Volume 25, Issue 1, January 2026.
Interrogation of the cellular and transcriptional profile of IMAT in individuals with KOA reveals a pro‐inflammatory phenotype. ABSTRACT Individuals with knee osteoarthritis (KOA) have skeletal muscle changes around the knee joint including reduced quadricep muscle mass and increased intermuscular adipose tissue (IMAT).
Line O. Elingaard‐Larsen, Katie L. Whytock, Adeline Divoux, Cheehoon Ahn, Giovanna Distefano, Bret H. Goodpaster, Paul M. Coen, Jamie N. Justice, Erin E. Kershaw, Nancy E. Lane, Lauren M. Sparks   +10 more
wiley   +1 more source

Broken-fat pad sign: a characteristic radiographic finding to distinguish between knee rheumatoid arthritis and osteoarthritis

Insights into Imaging
Objectives Diagnostic imaging plays an important role in the pre-treatment workup of knee osteoarthritis (OA) and rheumatoid arthritis (RA). Herein, we identified a useful MRI sign of infrapatellar fat pad (IPFP) to improve diagnosis.
Qizheng Wang, Weili Zhao, Xiaoxi Ji, Yongye Chen, Ke Liu, Yupeng Zhu, Ruixin Yan, Siyuan Qin, Peijin Xin, Ning Lang   +9 more
doaj   +1 more source

Synovitis in osteoarthritis: current understanding with therapeutic implications [PDF]

, 2017
Modern concepts of osteoarthritis (OA) have been forever changed by modern imaging phenotypes demonstrating complex and multi-tissue pathologies involving cartilage, subchondral bone and (increasingly recognized) inflammation of the synovium.
A Guermazi, A Guermazi, A Mathiessen, A Sarmanova, AD Gait, AD Pearle, Alexander Mathiessen, AS Siebuhr, BJ Lange-Brokaar de, BJ Lange-Brokaar de, BJ Lange-Brokaar de, BJ Lange-Brokaar de, C Deligne, CL Hill, CR Scanzello, CY Wenham, CY Wenham, CY Wenham, CY Wenham, D Hayashi, D Loeuille, DL Goldenberg, DT Felson, E Thomas, E Yusuf, F Berenbaum, F Ponchel, FW Roemer, FW Roemer, HI Keen, I Atukorala, I Prieto-Potin, IK Haugen, IK Haugen, IK Haugen, IR Klein-Wieringa, J Sellam, J Sokolove, JA Hamilton, JE Collins, K Baker, M Kloppenburg, MA D’Agostino, MB Goldring, MC Kortekaas, MC Kortekaas, MC Kortekaas, MD Smith, MF Pustjens, P Robinson, P Wojdasiewicz, PG Conaghan, PG Conaghan, Philip G. Conaghan, RG Riis, RH Roze, S Larsson, T Neogi, TW O’Neill, W Damman, W Zhang, X Wang, Y Zhang   +62 more
core   +2 more sources

Quercetin Alleviates Osteoarthritis Pain by Inhibiting Vascular Endothelial Growth Factor A Through Regulating cGAS/STING Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Knee osteoarthritis (KOA), a common degenerative joint disease marked by pain, inflammation and cartilage degradation, has been increasingly associated with dysregulated innate immune signalling. Among the implicated molecular pathways, cGAS/STING has emerged as a key modulator in both disease pathogenesis and therapeutic intervention ...
Enrui Hu, Yibao Wei, Taiyang Liao, Deren Liu, Zijian Gong, Jun Mao, Peimin Wang, Nongshan Zhang   +7 more
wiley   +1 more source

Patellar and Femoral Bone Morphology Is Associated With Overweight and Sports Participation in Young Adolescents

Journal of Orthopaedic Research, Volume 43, Issue 12, Page 2221-2232, December 2025.
ABSTRACT High levels of physical activity or high BMI during puberty could negatively influence bone and cartilage development. Little is known about the effects of loading on patellar and femoral bone shape in a young population. Therefore, we aim to identify the association between 3D patella and femur shape and biomechanical loading in a young ...
Rosemarijn van Paassen, Nazli Tumer, Jukka Hirvasniemi, Tom M. Piscaer, Amir.A. Zadpoor, Stefan Klein, Sita M. A. Bierma‐Zeinstra, Edwin H. G. Oei, Marienke van Middelkoop   +8 more
wiley   +1 more source

Augmentation and repair of tendons using demineralised cortical bone [PDF]

, 2016
BACKGROUND: In severe injuries with loss of tendon substance a tendon graft or a synthetic substitute is usually used to restore functional length. This is usually associated with donor site morbidity, host tissue reactions and lack of remodelling of the
Blunn, Gordon W., de Godoy, Roberta Ferro, Elnikety, Sherif, Holden, Charles, Pendegrass, Catherine J.   +4 more
core   +2 more sources

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

The treatment of patellar tendinopathy [PDF]

, 2013
Background Patellar tendinopathy (PT) presents a challenge to orthopaedic surgeons. The purpose of this review is to revise strategies for treatment of PT Materials and methods A PubMed (MEDLINE) search of the years 2002–2012 was performed using ...
Rodríguez Merchán, E. Carlos
core   +2 more sources

Cavernous Hemangioma of Hoffa’s Fat Pad: A Rare Case Presentation

Journal of Orthopaedic Case Reports
Introduction: Cavernous hemangiomas are benign vascular malformations composed of dilated, blood-filled channels, commonly occurring in cutaneous or subcutaneous tissues of the head, neck, or trunk. Their occurrence in the knee joint, particularly within
Shashanka Reddy, Praveen Manoharan, M Chakravarthi   +2 more
doaj   +1 more source