Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Nuclear physics with advanced brilliant gamma beams at ELI–NP
EPJ Web of Conferences, 2016 The Extreme Light Infrastructure - Nuclear Physics facility is dedicated to nuclear physics studies with the use of extreme electromagnetic radiation.
Ur Călin A. +5 more
doaj +1 more source
Uncovering a high-performance bio-mimetic cellular structure from trabecular bone
Scientific Reports, 2020 The complex cellular structure of trabecular bone possesses lightweight and superior energy absorption capabilities. By mimicking this novel high-performance structure, engineered cellular structures can be advanced into a new generation of protective ...
Abdallah Ghazlan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Optimal Placement and Sizing of Electric Vehicle Charging Infrastructure in a Grid-Tied DC Microgrid Using Modified TLBO Method [PDF]
, 2023 Nandini K. Krishnamurthy +6 more
openalex +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Integration of the Infrastructure of Systems Used in Smart Cities for the Planning of Transport and Communication Systems in Cities [PDF]
, 2021 Cezary Stępniak +3 more
openalex +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Arch dam point cloud segmentation based on deep feature learning and normal vector data optimization
Scientific ReportsSeparating the dam body, spillway, and other structures from the point cloud in the dam area is an important step in dam deformation monitoring. Manual segmentation is time consuming and inaccurate.
Huokun Li +6 more
doaj +1 more source
Research on Seismic Performance of Frame Structure with Beam Staircases
Buildings, 2022 Beam staircases are widely used in frame structures. In structural design, stair flights are often ignored in the model establishment, and their loads are only added to the stair beams.
Ming Wen +4 more
doaj +1 more source