Results 41 to 50 of about 582,038 (244)

Investigator-initiated clinical trials conducted by the Portuguese Clinical Research Infrastructure Network (PtCRIN)

Contemporary Clinical Trials Communications, 2016
Interventional clinical studies can provide the highest levels of evidence and generate significant results on specific investigational medicinal products or medical devices.
C. Madeira, A. Pais, C. Kubiak, J. Demotes, E.C. Monteiro   +4 more
doaj   +1 more source

Infrastructuring Publics: Datafied Infrastructures of the News Media

, 2023
This chapter examines the digital infrastructure connected to media website architecture and discusses effects of such infrastructures on journalistic ideals of providing the information needed to enable a democratic public (cf Strömbäck, 2005; Fenton, 2010).
Kristensen, Lisa Merete, Sørensen, Jannick Kirk; id_orcid 0000-0002-4127-6551   +1 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Nuclear physics with advanced brilliant gamma beams at ELI–NP

EPJ Web of Conferences, 2016
The Extreme Light Infrastructure - Nuclear Physics facility is dedicated to nuclear physics studies with the use of extreme electromagnetic radiation.
Ur Călin A., Filipescu Dan, Gheorghe Ioana, Iancu Violeta, Suliman Gabriel, Teşileanu Ovidiu   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Uncovering a high-performance bio-mimetic cellular structure from trabecular bone

Scientific Reports, 2020
The complex cellular structure of trabecular bone possesses lightweight and superior energy absorption capabilities. By mimicking this novel high-performance structure, engineered cellular structures can be advanced into a new generation of protective ...
Abdallah Ghazlan, Tuan Ngo, Tuan Nguyen, Steven Linforth, Tu Van Le   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Arch dam point cloud segmentation based on deep feature learning and normal vector data optimization

Scientific Reports
Separating the dam body, spillway, and other structures from the point cloud in the dam area is an important step in dam deformation monitoring. Manual segmentation is time consuming and inaccurate.
Huokun Li, Yuekang Li, Yijing Li, Weichao Lu, Zhixing Zhu, Teng Feng, Bo Liu   +6 more
doaj   +1 more source

Planning paradigms throughout economic history

Історія науки і техніки
Planning has always been an essential part of scientific and practical activities, driven by the need for purposeful development in science, technology and society.
Olha Kravchenko, Olga Shkurenko, Svitlana Bonіar, Svitlana Shuliarenko   +3 more
doaj   +1 more source