Results 41 to 50 of about 3,545,696 (359)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

PREFACE

Історія науки і техніки, 2020
The year 2020, verging to a close, is one of the most difficult and hardest years in the life of mankind over the last century. Unfortunately, it is in the 20th year of each century for the last several hundred years that human civilization has been ...
Oleh Pylypchuk, Oleh Strelko, Yulia Berdnychenko   +2 more
doaj   +3 more sources

Infrastructuring Publics: Datafied Infrastructures of the News Media

, 2023
This chapter examines the digital infrastructure connected to media website architecture and discusses effects of such infrastructures on journalistic ideals of providing the information needed to enable a democratic public (cf Strömbäck, 2005; Fenton, 2010).
Kristensen, Lisa Merete, Sørensen, Jannick Kirk; id_orcid 0000-0002-4127-6551   +1 more
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Investigator-initiated clinical trials conducted by the Portuguese Clinical Research Infrastructure Network (PtCRIN)

Contemporary Clinical Trials Communications, 2016
Interventional clinical studies can provide the highest levels of evidence and generate significant results on specific investigational medicinal products or medical devices.
C. Madeira, A. Pais, C. Kubiak, J. Demotes, E.C. Monteiro   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Nuclear physics with advanced brilliant gamma beams at ELI–NP

EPJ Web of Conferences, 2016
The Extreme Light Infrastructure - Nuclear Physics facility is dedicated to nuclear physics studies with the use of extreme electromagnetic radiation.
Ur Călin A., Filipescu Dan, Gheorghe Ioana, Iancu Violeta, Suliman Gabriel, Teşileanu Ovidiu   +5 more
doaj   +1 more source

”Why are they all obsessed with Gender?” — (Non)binary Navigations through Technological Infrastructures [PDF]

, 2021
Katta Spiel
openalex   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source