Results 41 to 50 of about 626,696 (266)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Arch dam point cloud segmentation based on deep feature learning and normal vector data optimization
Scientific ReportsSeparating the dam body, spillway, and other structures from the point cloud in the dam area is an important step in dam deformation monitoring. Manual segmentation is time consuming and inaccurate.
Huokun Li +6 more
doaj +1 more source
Uncovering a high-performance bio-mimetic cellular structure from trabecular bone
Scientific Reports, 2020 The complex cellular structure of trabecular bone possesses lightweight and superior energy absorption capabilities. By mimicking this novel high-performance structure, engineered cellular structures can be advanced into a new generation of protective ...
Abdallah Ghazlan +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Planning paradigms throughout economic history
Історія науки і технікиPlanning has always been an essential part of scientific and practical activities, driven by the need for purposeful development in science, technology and society.
Olha Kravchenko +3 more
doaj +1 more source
Interface Focus, 2016 Abstract Design, construction, maintenance and upgrading of civil engineering infrastructure requires fresh thinking to minimize use of materials, energy and labour. This can only be achieved by understanding the performance of the infrastructure, both during its construction and throughout its design life, through innovative ...
Soga, Kenichi, Schooling, Jennifer
openaire +4 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
EJNMMI PhysicsRecent advancements in nuclear medicine, particularly in personalised radiopharmaceutical therapy, have emphasised the growing need for precise assessments of therapeutic safety and efficacy.
Kaluzi Banda +6 more
doaj +1 more source
Contemporary Clinical Trials Communications, 2016 Interventional clinical studies can provide the highest levels of evidence and generate significant results on specific investigational medicinal products or medical devices.
C. Madeira +4 more
doaj +1 more source