Results 51 to 60 of about 756,074 (294)
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Buildings, 2022 To improve the safety performance of important rooms, such as operating rooms and disaster command centers, during an earthquake, a novel partial seismic isolation system suitable for new and existing frame structures is proposed, and the seismic and ...
Baokui Chen +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Openness as Infrastructure [PDF]
Nature Precedings, 2011 AbstractOpenness at the layer of cultural works and data is the key to the data infrastructure we need to accelerate science. This article lays out three key elements of data infrastructure - collaboration, classification, and openness - which draw us inevitably towards the long-claimed, but rarely-achieved, goal of the scientific method: to make ...
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Nineteenth-Century Infrastructures before ‘Infrastructure’
19: Interdisciplinary Studies in the Long Nineteenth Century, 2023 What is at stake when we bring nineteenth-century projects into dialogue with critical infrastructure studies? This introduction highlights the conceptual, material, and geopolitical stakes of Victorian infrastructure, as explored in contributions to this issue of 19. By opening up margins of contested meaning in and around large-scale systems during a
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Planning paradigms throughout economic history
Історія науки і технікиPlanning has always been an essential part of scientific and practical activities, driven by the need for purposeful development in science, technology and society.
Olha Kravchenko +3 more
doaj +1 more source
The Use of a Fault Tree Analysis (FTA) in the Operator Reliability Assessment of the Critical Infrastructure on the Example of Water Supply System [PDF]
, 2022 Krzysztof Boryczko +3 more
openalex +1 more source