Results 61 to 70 of about 1,635,617 (361)

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Investigator-initiated clinical trials conducted by the Portuguese Clinical Research Infrastructure Network (PtCRIN)

Contemporary Clinical Trials Communications, 2016
Interventional clinical studies can provide the highest levels of evidence and generate significant results on specific investigational medicinal products or medical devices.
C. Madeira, A. Pais, C. Kubiak, J. Demotes, E.C. Monteiro   +4 more
doaj   +1 more source

Infrastructuring Publics: Datafied Infrastructures of the News Media

, 2023
This chapter examines the digital infrastructure connected to media website architecture and discusses effects of such infrastructures on journalistic ideals of providing the information needed to enable a democratic public (cf Strömbäck, 2005; Fenton, 2010).
Kristensen, Lisa Merete, Sørensen, Jannick Kirk   +1 more
openaire   +2 more sources

Enhancing patient engagement in cancer research: a focus on patient‐centric approaches to scientific discovery

Molecular Oncology, EarlyView.
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda, Marina Reguero, Vanesa Abón, Marta Puyol   +3 more
wiley   +1 more source

Nuclear physics with advanced brilliant gamma beams at ELI–NP

EPJ Web of Conferences, 2016
The Extreme Light Infrastructure - Nuclear Physics facility is dedicated to nuclear physics studies with the use of extreme electromagnetic radiation.
Ur Călin A., Filipescu Dan, Gheorghe Ioana, Iancu Violeta, Suliman Gabriel, Teşileanu Ovidiu   +5 more
doaj   +1 more source

CYC: a large-scale investment in knowledge infrastructure

CACM, 1995
Since 1984, a person-century of effort has gone into building CYC, a universal schema of roughly 105 general concepts spanning human reality. Most of the time has been spent codifying knowledge about these concepts; approximately 106 commonsense axioms ...
D. Lenat
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Ritornello: “People as Infrastructure”

Urban Geography, 2021
“People as Infrastructure” was a concept deployed by the author in a 2004 publication of Public Culture. This essay returns to this notion following widespread use across the urban studies community, and attempts to find new dimensions of applicability
AbdouMaliq Simone
semanticscholar   +1 more source

Experimenting with Infrastructures

2010 5th International Conference on Critical Infrastructure (CRIS), 2010
Laboratory environments for experimenting on infrastructures are often challenging both technically, politically and economically. The situation is further complicated when the interaction between infrastructures is in focus rather than the behaviours of a singular one.
Ståhl, Björn, Caire, Raphael, Thany, Luc Le, Gustavsson, Rune   +3 more
openaire   +5 more sources

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source