Results 31 to 40 of about 46,879 (279)

THE LIMITS OF RECOURSE TO FORCE IN THE CONTEXT OF CONTEMPORARY GEOPOLITICS [PDF]

open access: yesChallenges of the Knowledge Society, 2019
Recourse to force represents a highly controversial subject matter, given its political sensitivity, as well as the legal framework that authorizes it.
Sandra Sophie-Elise OLĂNESCU
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Doctoral Student’s Responsibility for Violation of Ethical Standards During Doctoral Studies

open access: yesEIRP Proceedings, 2022
Intellectual property law enjoys the most expansive and branching evolution of the last century, both in terms of national regulations and in terms of signed international conventions and adopted Community directives, as evidenced even by established ...
Maria Cristiana Ieremie
doaj  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Patent Infringement by ANDA Filing [PDF]

open access: yes, 2023
Courts are in general designed to adjudicate past events (e.g., crimes and torts which have already occurred).  Thus, for example, proving patent infringement merely requires showing the court the on-market product, and comparing it to the patent at ...
Pohl, Mark ; Registered Patent Attorney Pharmaceutical Patent Attorneys, Llc 55 Madison Avenue, 4th Floor Morristown, Nj 07960-7397 USA
core   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Striking the Right Chord: Legal Dynamics of Music Copyright Law in Malaysia

open access: yesAsian Journal of Law and Policy
Copyright law is the bedrock of the music industry, governing the ownership, distribution and commercialisation of musical works and sound recordings.
Liveernieesh Ramakrishnan
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

EFFECTIVENESS OF EU LAW IN MEMBER STATES [PDF]

open access: yesChallenges of the Knowledge Society, 2011
When the original Rome Treaty was drafted, it was envisaged by the authors that the procedure as set out in what is now article 258 T.F.E.U. (infringement procedure) would be the primary means by which EU law is enforced - a “centralized” and “public ...
ANCA-MAGDA VLAICU
doaj  

La creencia en la supremacía de la voluntad propia en la violación de normas de tránsito [PDF]

open access: yesAposta, 2020
Este artículo presenta un trabajo de investigación acerca de la problemática de los atropellos a peatones y choques entre vehículos que ocurren como consecuencia de la adopción de conductas violatorias de las normas en Argentina y Chile.
Gabriel Escanés
doaj  

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