Results 51 to 60 of about 295,269 (275)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Mathematical models of gear rattle in Roots blower vacuum pumps [PDF]

open access: yes, 2006
This paper is concerned with the modelling of gear rattle in Roots blower vacuum pumps. Analysis of experimental data reveals that the source of the noise and vibration problem is the backlash nonlinearity due to gear teeth losing and re-establishing ...
Wilson, RE   +6 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Estimation of median effective effect-site concentration (EC50) during target-controlled infusion of propofol for dilatation and curettage – A prospective observational study

open access: yesIndian Journal of Anaesthesia, 2022
Background and Aims: Propofol is the drug of choice for sedation in daycare procedures due to its pharmacokinetic properties. Propofol delivery using target-controlled infusion (TCI) pump reduces adverse effects like hypotension and apnoea. In this study,
Velraj Jaya   +3 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

VP189 Hemolysis Induced By Modern Infusion Pumps During Blood Transfusion

open access: yes, 2017
INTRODUCTION:Following a first field evaluation conducted in 2013, we found that hemolysis can be induced by infusion pumps during blood transfusion.
Nathalie Carrier   +6 more
core   +1 more source

Impact of Physical Parameters on Dosing Errors due to a Syringe Exchange in Multi-Infusion Therapy

open access: yesPharmaceutical Technology in Hospital Pharmacy, 2017
Infusion therapy is challenging and dosing errors may occur due to physical phenomena related to the infusion hardware, despite the use of accurate syringe pumps. These errors typically occur after interventions, such as the exchange of a syringe.
Snijder Roland A.   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Bombas de infusão: operação, funcionalidade e segurança [PDF]

open access: yes, 2002
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.
Alves, Márcio Alexandre de Castro
core  

Consensus on neonatal infusion pumps and pressure monitoring

open access: yes, 2005
Wilkins and Emmerson 1 highlighted the lack of consensus on the management of extravasation injuries in neonates. Modern neonatal infusion pumps can measure inline intravenous pressure and could theoretically detect early infiltration and subsequent ...
Gnanalingham, M., Irving, V., Shaw, N J
core   +1 more source

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