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Large-volume intrathecal administrations: impact on CSF pressure and safety implications [PDF]
The increasing number of studies demonstrates the high potency of the intrathecal (IT) route for the delivery of biopharmaceuticals to the central nervous system (CNS). Our earlier data exhibited that both the infused volume and the infusion rate can regulate the initial disposition of the administered solute within the cerebrospinal fluid (CSF).
arxiv
Abstract Background Better understanding the impact of dietetic services on nutrition practices seems required as it may represent an opportunity for optimization in post–cardiac surgery patients. The present study aims to evaluate and compare nutrition practices and clinical outcomes in post–cardiac surgery intensive care unit (ICU) patients with and ...
Ellen Dresen+19 more
wiley +1 more source
Managing pregnancy with long‐term parenteral nutrition: A case report and review of the literature
Abstract Parenteral nutrition (PN) is essential for patients with chronic intestinal failure but poses significant challenges during pregnancy because of increased nutrition needs and associated risks such as central line–associated bloodstream infections. We report a case of a 29‐year‐old primigravid woman with Crohn's disease who required chronic PN.
Muhammad Shahzil+6 more
wiley +1 more source
Apesar da introdução da quelação parenteral de ferro com desferoxamina há mais de trinta anos, 50% dos pacientes com talassemia major morrem antes dos 35 anos de idade, predominantemente por insuficiência cardíaca secundária a sobrecarga de ferro. Embora
Antonio Fabron Jr, Fernando Tricta
doaj +1 more source
Abstract With advancements in neonatal care, the viability of extremely low‐birth‐weight (ELBW) infants, especially those born extremely preterm, is increasing. However, specific recommendations for managing parenteral nutrition (PN) support in nanopreterm infants (<750 g or <25 weeks' gestation) are lacking.
Mar Romero‐Lopez+4 more
wiley +1 more source
Delay in desmopressin therapy: Disaster in waiting
There is little information on the onset of hypernatremia after withdrawal of desmopressin. We present a case of an elderly woman with central DI whose serum sodium jumped from 141 to 171 mEq/L after 48‐72 h of holding oral desmopressin. Based on this precipitous onset of DI crisis, we recommend not withholding desmopressin for more than 24 h. Abstract
Christian Kroll, Arya Zandvakili
wiley +1 more source
Smart implanted access port catheter for therapy intervention with pH and lactate biosensors
Totally implanted access ports (TIAP) are widely used with oncology patients requiring long term central venous access for the delivery of chemotherapeutic agents, infusions, transfusions, blood sample collection and parenteral nutrition.
Bruno Gil+5 more
doaj
In-patient management of diabetes: Controversies and guidelines
Hyperglycemia is associated with adverse outcomes in hospitalized patients with and without previously known diabetes. Some therapies that are used in the in-patient setting, including glucocorticoids, enteral and parenteral nutrition are associated with
Mary T Korytkowski
doaj +1 more source
DGAT‐1 deficiency: Congenital diarrhea and dietary treatment
Abstract DGAT‐1 (Diacylglycerol Acyltransferase‐1) deficiency is an autosomal recessive disorder which causes severe impairment in lipid absorption. We report a case of an infant suffering from persistent diarrhea starting at the age of four weeks. Further investigations identified DGAT‐1 deficiency as underlying cause.
Clemens Gardemann+6 more
wiley +1 more source
Specific fatty acids as metabolic modulators in the dairy cow
This review summarizes recent developments on the utilization of specific fatty acids to modulate bovine energy metabolism, with emphasis on the periparturient dairy cow. A number of experiments have assessed the effects of polyunsaturated fatty acids on
J.A.A. Pires, R.R. Grummer
doaj +1 more source