Results 81 to 90 of about 543,288 (335)

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik, Ainhoa Gomez‐Lumbreras, Guilherme Del Fiol, Kensaku Kawamoto, Katy E. Trinkley, Thomas Reese, Aubrey Jones, Daniel C. Malone   +7 more
wiley   +1 more source

Infusión prolongada de ketamina y pruebas de función hepática [PDF]

Revista Chilena de Anestesia, 2023
Yerlin Andrés Colina Vargas, William Henry Joaqui Tapia, Cristina Posada Giraldo, Santiago Barrientos Henao, Cristian Vera Marín, José Julián Aristizábal   +5 more
doaj   +1 more source

Outpatient treatment of decompensated heart failure: A systematic review and study level meta‐analysis

ESC Heart Failure, Volume 12, Issue 2, Page 761-769, April 2025.
Abstract Patients with acutely decompensated heart failure (ADHF) are usually admitted to hospital for management. There is growing interest in delivering intravenous (IV) diuretic therapy at home, in the community or at hospital day‐care units; the safety and effectiveness of outpatient‐based management (OPM) for ADHF has not been established.
Jameela Bahar, Amna Rahman, Grace W.Y. Wong, Rajiv Sankaranarayanan, Fozia Z. Ahmed, Rebecca Taylor, Ahmet Fuat, Iain Squire, John G.F. Cleland, Gregory Y.H. Lip, James H.P. Gamble, Sundas Masudi, Prince Josiah S. Joseph, Kenneth Y.K. Wong   +13 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Seizures and electroencephalographic findings in inborn errors of metabolism: Clues to differential diagnosis in the neonatal period, infancy, childhood and adolescence, and review of the literature

Epileptic Disorders, EarlyView.
Abstract Although inborn errors of metabolism (IEM) are a rare cause of epilepsy, seizures are a common presentation in these disorders. Seizures in IEM are frequently refractory to conventional anti‐seizure medication and might warrant initiation of specific treatments based on vitamins or dietary modifications or provision of alternative substrates ...
D. Kapoor, S. Sharma, A. Kaminska, R. Nabbout, N. Chemaly, M. Schiff, P. De Lonlay, M. Eisermann   +7 more
wiley   +1 more source

Cetuximab Hypersensitivity in the Setting of Asymptomatic Alpha‐Gal Sensitization

Head &Neck, EarlyView.
ABSTRACT Background Alpha‐gal syndrome is an allergic condition resulting from the bite of the Lonestar tick in the southeastern US that leads to sensitization to mammalian products containing the oligosaccharide galactose‐alpha‐1,3‐galactose (alpha‐gal).
Alexander G. Emerson, Lindsay Mundy, Barbara A. Murphy, Cosby A. Stone   +3 more
wiley   +1 more source

A causal inference framework to compare the effectiveness of life‐sustaining ICU therapies—using the example of cancer patients with sepsis

International Journal of Cancer, EarlyView.
What's New? Rising cancer incidence in the United States is associated with an increased demand on intensive care units (ICUs). Critically ill cancer patients, however, often rely on life‐sustaining therapies, which are linked to greater ICU mortality.
João Matos, Tristan Struja, Naira Link Woite, David Restrepo, Andre Kurepa Waschka, Leo A. Celi, Christopher M. Sauer   +6 more
wiley   +1 more source

Lymphocytes cross-matching as retrospective tool for hyper-acute rejection diagnosis in heart transplantation.

Transplantation Reports, 2020
Background: Lymphocyte cross-matching (CDC) is considered as important screening test that is unfrequently performed preoperatively in heart transplantation procedures.
Tomasz Urbanowicz, Dominika Konecka-Mrówka, Jerzy Nożyński, Marek Jemielity   +3 more
doaj   +1 more source

Relationship Between Hyperglycemia and Infection in Critically Ill Patients [PDF]

, 2005
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90178/1/phco.2005.25.7.963 ...
Alexiewicz, Alverdy, Bagdade, Cesar Alaniz, Chandra, Fietsam, Garber, Imad F. Btaiche, Knapke, Malmberg, Malmberg, Perner, Pomposelli, Rossini, Simona O. Butler, Van Oss, Wolfe   +16 more
core   +1 more source

Controlled-release of opioids for improved pain management [PDF]

, 2016
The adequate treatment of pain remains one of the major medical challenges. Morphine and other opioid drugs are most commonly used to counteract moderate to severe pain, but they are also increasingly accessed by patients with chronic non-malignant pain.
Ballet, Steven, De Baerdemaeker, Andy, Hoogenboom, Richard, Madder, Annemieke, Martin, Charlotte, Poelaert, Jan   +5 more
core   +1 more source