Results 51 to 60 of about 98,970 (350)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Real life pharmaceutical treatment patterns for adult patients with focal epilepsy in Germany: a longitudinal and cross-sectional analysis of recently approved anti-epileptic drugs

GMS German Medical Science, 2017
Objectives: The aim of this study was to investigate the antiepileptic drug (AED) treatment of adults suffering from focal epilepsies (FE) in Germany.
Groth, Antje, Wilke, Thomas, Borghs, Simon, Gille, Patrick, Joeres, Lars   +4 more
doaj   +1 more source

Venus Express radio occultation observed by PRIDE [PDF]

, 2019
Context. Radio occultation is a technique used to study planetary atmospheres by means of the refraction and absorption of a spacecraft carrier signal through the atmosphere of the celestial body of interest, as detected from a ground station on Earth ...
Bocanegra-Bahamon, T. M., Calves, G. Molera, Cimo, G., Cui, L., Dirkx, D., Duev, D. A., Gurvits, L. I., Ipatov, A. V., Kharinov, M. A., Kondo, T., Li, P., Limaye, S., Lovell, J. E. J., Ma, M., McCallum, J. N., Mikhailov, A. G., Pogrebenko, S. V., Rosenblatt, P., Sekido, M., Wang, W., Zheng, W.   +20 more
core   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Burden of hospitalization in acute lymphoblastic leukemia patients treated with Inotuzumab Ozogamicin versus standard chemotherapy treatment

Cancer Medicine, 2019
Background Inotuzumab Ozogamicin (INO), has demonstrated an improvement in overall survival, high rate of complete remission, favorable patient‐reported outcomes, and manageable safety profile vs standard of care (SoC; intensive chemotherapy) for ...
David I. Marks, Ilse vanOostrum, Sabrina Mueller, Verna Welch, Erik Vandendries, Fausto R. Loberiza, Sarah Böhme, Yun Su, Matthias Stelljes, Hagop M. Kantarjian   +9 more
doaj   +1 more source

Prime Example Ingress Reframing the Pervasive Game Design Framework (PGDF)

International Journal of Serious Games, 2017
The growing availability of mobile communication infrastructure over the last decade has contributed significantly to the maturity of Pervasive Gaming. The massive success of games such as Ingress and Pokémon Go made pervasive gaming a viable option for ...
Heinrich Söbke, Jannicke Baalsrud Hauge, Ioana Andreea Stefan   +2 more
doaj   +1 more source

The structure of Chariklo's rings from stellar occultations [PDF]

, 2017
Two narrow and dense rings (called C1R and C2R) were discovered around the Centaur object (10199) Chariklo during a stellar occultation observed on 2013 June 3.
Alonso, S., Assafin, M., Backes, M., Barry, M. A., Bath, K. L., Beisker, W., Benedetti-Rossi, G., Blain, A., Bode, H. J., Bradshaw, J., Braga-Ribas, F., Breytenbach, H., Brillant, S., Broughton, J., Bérard, D., Camargo, J. I. B., Carraro, G., Colas, F., Colazo, C., Cole, A., Cool, A., Dauvergne, J. L., Davis, L., De Witt, C., Desmars, J., Duffard, R., Dumas, C., Dunham, D., Gault, D., Genade, A., Giles, D., Gillon, M., Gomes-Júnior, A. R., Herald, D., Herrera, C., Hill, K. M., Horvart, R., Irawati, P., Ivanov, V. D., Jaquiery, P. D., Jehin, E., Kerr, S., Kervella, P., Lade, B., Lecacheux, J., Leiva, R., Loader, B., Maestre, J. L., Manfroid, J., Maquet, L., Maury, A., Maybour, D., Melia, R., Meza, E., Monaco, L., Monard, B., Morales, N., Newman, J., Ortiz, J. L., Paton, R. A., Pavlov, H., Pennell, A., Peyrot, A., Pollock, J., Prager, R., Renner, S., Richichi, A., Rizos, J. L., Roland, S., Román, A, Salvo, R., Santos-Sanz, P., Schoenau, P., Selman, F., Sicardy, B., Sickafoose, A. A., Spagnotto, J., Tancredi, G., Teng-Chuen-Yu, J. P., Vachier, F., Vanzi, L., Vieira-Martins, R.   +81 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source