Results 221 to 230 of about 47,386 (299)

Mouse Vocal Fold Permeability In Vivo: Effects of Novel Low‐Tech Injury and Instillation Methods

The Laryngoscope, EarlyView.
Improving experimental mouse vocal fold injury and instillation approaches is necessary to advance preclinical models of laryngeal disease. We have successfully repurposed low‐tech, quick, and reliable injury and instillation methods established in respiratory research. Using these methods, we show that murine vocal fold epithelium is inherently highly
Renee E. King, Ella T. Ward‐Shaw, Paul F. Lambert   +2 more
wiley   +1 more source

Increasing Infusion Times of Hyperpolarized [1‐13C]Pyruvate in a Mouse Brain Maintain Lactate Generation and Approach Pseudo‐Steady State Metabolism

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To investigate whether varying delivery times of hyperpolarized [1‐13C]pyruvate, enabled by the increased apparent T1 dissolved in deuterium oxide (D2O), affects the observed kinetics of glycolytic brain metabolism in vivo. Methods Eighteen healthy mice were injected with 300 μL of hyperpolarized [1‐13C]pyruvate dissolved in D2O at ...
Paola Porcari, Vesselin Miloushev, Saket Patel, Thasin Peyear, Marjan Berishaj, Kayvan R. Keshari   +5 more
wiley   +1 more source

Multiparametric MRI to Predict Response to Irreversible Electroporation Plus Anti‐PD‐1 Immunotherapy in Pancreatic Ductal Adenocarcinoma

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To investigate contrast‐enhanced T1‐weighted MRI and diffusion‐weighted magnetic resonance imaging (DWI) for early prediction of tumor response to combined irreversible electroporation (IRE) and anti‐PD‐1 immunotherapy. Methods Murine pancreatic ductal adenocarcinoma (PDAC) cells KRAS* were inoculated into the pancreas of C57BL/6 mice.
Qizhen Cao, Mark D. Pagel, Charles V. Kingsley, Jingfei Ma, James P. Long, Xiaoxia Wen, Seth T. Gammon, Jorge Delacerda, Sanaz Javadi, Chun Li   +9 more
wiley   +1 more source

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

Neuroprotection, EarlyView.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai, Qing Nan, Menglu Xu, Hongbao Li   +3 more
wiley   +1 more source

Spinal cord transection repair occurs when Nestin+ cells differentiate into neurons within a taxol‐collagen‐enhanced microenvironment in mice

Neuroprotection, EarlyView.
We utilized Nestin‐CreER:tdTomato transgenic mice to directly illustrate that taxol could induce the differentiation of neural stem cells (NSCs) into neurons. This process promoted the formation of a nerve bridge connecting the two ends of the injury, ultimately resulting in the functional improvement of spinal cord injury (SCI) animals.
Caixia Fan, He Jiang, Junyan Yan, Lifang Jin, Guoquan Fu, Weiwei Xue, Lulu Zhang   +6 more
wiley   +1 more source

Predicting Anxiety in Children Aged 2–6 During Preoperative Anesthesia Consultation—A Prospective Observational Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Preoperative Anxiety in Young Children Is Common and Can Lead to Adverse Outcomes. In Clinical Routine, Anesthesiologists Must Often Predict Anxiety Based on Limited Interaction. Aims This study aimed to evaluate the accuracy of early anxiety predictions and to identify early predictors of heightened anxiety at anesthesia induction.
Armin Sablewski, Charlotte Neitzel, Maximilian Grosser, Katarina Krebs, Anna Karstensen, Alina Balandin, Helene Selpien, Tobias Becher   +7 more
wiley   +1 more source

Glucocorticoid‐Induced TNFR‐Related Ligand as a Biomarker for Diagnosis and Severity of Asthma in Children

Pediatric Discovery, EarlyView.
Our study demonstrates elevated GITRL expression in HDM‐exposed dendritic cells (in vitro), murine asthma models, and pediatric asthma patients, and reveals a direct association between GITRL levels and disease severity in children. ABSTRACT Currently, there are no reliable pediatric biomarkers for assessing the severity of asthma. Therefore, the study
Yuehan Li, Yan Li, Jinying Xiang, Yinying Ren, Mi Zhou, Fang Deng, Zhou Fu, Fengxia Ding   +7 more
wiley   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Comparison of Total Intravenous Anesthesia (TIVA) with Inhalation Anesthesia in Pediatric Bronchoscopy

, 2013
Majid Razavi, Alireza Bameshki, Saeed Jahanbakhsh, Alireza Sabzevari, Mehryar Taghavi Gilani   +4 more
openalex   +1 more source