Results 231 to 240 of about 47,386 (299)

eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

open access: yesSmall, EarlyView.
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha   +6 more
wiley   +1 more source

Hydrogel Microneedle Array‐Based Transdermal Dressing System for Multiplexed Assessment and Intelligent Therapy of Chronic Wounds

open access: yesSmall, EarlyView.
This work develops a theranostic wound microneedle dressing integrates a therapeutic MXene‐infused hydrogel with a high‐conductive sensor array enabled by a novel laser‐scribing technique. The platform actively promotes wound healing and provides antibacterial action while continuously monitoring seven key biomarkers.
Md Sharifuzzaman   +6 more
wiley   +1 more source

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

open access: yesSmall, EarlyView.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad   +11 more
wiley   +1 more source

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