Results 221 to 230 of about 18,601 (330)

Myosin VI Is Associated With the Endoplasmic Reticulum in Regions of Sertoli Cells Containing Tubulobulbar Complexes

open access: yesCytoskeleton, EarlyView.
ABSTRACT Myosin VI has been reported by others to localize in association with various regions of apical tubulobulbar complexes (TBCs) at sites of attachment between Sertoli cells and late spermatids in the mouse. Tubulobulbar complexes internalize “intact” intercellular junctions during sperm release and during spermatocyte translocation through the ...
Samuel Tretjakov   +2 more
wiley   +1 more source

β‐Glucuronidase‐Responsive Albumin‐Binding Prodrug of Colchicine‐Site Binders for Selective Cancer Therapy

open access: yesChemMedChem, Volume 20, Issue 9, May 5, 2025.
This study presents a β‐glucuronidase‐responsive albumin‐binding prodrug enabling the selective release within the tumor microenvironment of an Isocombretastatin A‐4 analog. In triple‐negative breast cancer (TNBC) mouse models, this prodrug demonstrated significant tumor growth inhibition, highlighting potential for enhanced therapeutic selectivity and
Alexandra Bordes   +6 more
wiley   +1 more source

Rat Strain Minimally Influences Anesthetic and Convulsant Requirements of Inhaled Compounds in Rats

open access: bronze, 1998
Diane Gong   +5 more
openalex   +1 more source

Tackling Environmental Impact: A New Support Tool for Sustainable Healthcare Waste Management

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study proposes a novel framework integrating Environmental Risk Assessment (ERA) and Material Flow Analysis (MFA) within the Deming Cycle framework to address this gap. While valuable tools, ERA and MFA offer limited perspectives on environmental impact when used alone.
Carlotta D'Alessandro   +4 more
wiley   +1 more source

Beta2‐adrenergic agonist salbutamol exhibits enantioselective disposition in skeletal muscle of lean young men following oral administration

open access: yesDrug Testing and Analysis, EarlyView.
Oral administration of salbutamol shows enantioselective disposition in human skeletal muscle, favoring the (S)‐enantiomer with higher relative partitioning of the pharmacologically active (R)‐enantiomer in muscle. This is concerning from an anti‐doping point of view because the anabolic properties demonstrated for salbutamol can potentially be ...
Morten Hostrup   +5 more
wiley   +1 more source

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