Results 251 to 260 of about 352,671 (284)

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

Neuroprotection, EarlyView.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai, Qing Nan, Menglu Xu, Hongbao Li   +3 more
wiley   +1 more source

Glucocorticoid‐Induced TNFR‐Related Ligand as a Biomarker for Diagnosis and Severity of Asthma in Children

Pediatric Discovery, EarlyView.
Our study demonstrates elevated GITRL expression in HDM‐exposed dendritic cells (in vitro), murine asthma models, and pediatric asthma patients, and reveals a direct association between GITRL levels and disease severity in children. ABSTRACT Currently, there are no reliable pediatric biomarkers for assessing the severity of asthma. Therefore, the study
Yuehan Li, Yan Li, Jinying Xiang, Yinying Ren, Mi Zhou, Fang Deng, Zhou Fu, Fengxia Ding   +7 more
wiley   +1 more source

Good Practice in Postoperative and Procedural Pain Management 2nd Edition [PDF]

, 2012
CARTER, BERNIE, Curry, Joe, Howard, Richard, Jain, Anoo, Liossi, Christina, Morton, Neil, Rivett, Kate, Rose, Mary, Tyrell, Jennifer, Walker, Suellen, Williams, Glynn   +10 more
core  

Atomic Force Microscopy‐Based Nanomechanical Signatures for Staging Classification and Drug Response in Pulmonary Fibrosis

Small, EarlyView.
Atomic Force Microscopy (AFM) reveals nanomechanical fingerprints (NMFs) that track the progression of pulmonary fibrosis (PF) and response to therapy. These NMFs correlate with collagen I content and gene expression, offering a novel biomarker for disease staging and treatment monitoring.
Andreas Stylianou, Katerina Polemidiotou, Vassilis Alimisis, Fotios Mpekris, Chrysovalantis Voutouri, Meropi Mari, George Filippidis, Andreas Zachariades, Stylianos‐Vasileios Kontomaris, Paul P Sotiriadis, Vasiliki Gkretsi, Triantafyllos Stylianopoulos   +11 more
wiley   +1 more source

Targeted Nanocomplex Delivery for Protecting Vascular Integrity and Enhancing Anticancer Effects in Hepatocellular Carcinoma

Small Science, EarlyView.
Herein, a liver‐targeted nanohybrid formulation, SGLC/DOX@AG, is developed to enhance doxorubicin delivery and reduce vascular toxicity in hepatocellular carcinoma (HCC) treatment. Incorporating an albumin–glucosamine lipid complex, the system shows potent anticancer effects and minimized side effects across in vitro, in vivo, and cancer‐on‐a‐chip ...
Hyelim Kim, Han Sol Lee, June Hong Ahn, Tae‐Wan Kwon, So‐Yeol Yoo, Donghyuk Seo, Sang Kyum Kim, Hee Ho Park, Seung‐Woo Cho, Wonhwa Lee, Jae‐Young Lee, Hong Nam Kim   +11 more
wiley   +1 more source

Neuroprotective effects of remote limb ischemic preconditioning through enhanced cerebral blood flow via activation of the PI3K/AKT pathway in ischemic stroke

VIEW, EarlyView.
Stroke is a leading cause of death and disability worldwide, often due the inadequate restoration of cerebral blood flow following vascular recanalization. Our study demonstrates that a simple technique called RLIPC (remote limb ischemic preconditioning), which involves briefly restricting blood flow in a limb, protects the brain during a stroke by ...
Chaoran Dou, Diwen Tang, Yulin Yan, Wen Shui, Minzhi Zhou, Bin Chen, Lishuai Feng, Benhao Li, Tao Ying   +8 more
wiley   +1 more source

Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies

VIEW, EarlyView.
Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan, Wangzheqi Zhang, Yan Liao, Chenglong Zhu, Xiaojing Guo, Zui Zou, Mi Li   +6 more
wiley   +1 more source

Focusing on an EEG Biomarker, the Photoparoxysmal Response (PPR), to Identify Promising Investigational Anti‐Seizure Medications (ASMs) and Differentiate the Efficacy of Existing ASMs

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Ronald C. Reed, Dorothee G. A. Kasteleijn‐Nolst Trenite   +1 more
wiley   +1 more source

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Association between genotoxic properties of inhalation anesthetics and oxidative stress biomarkers

Toxicology and industrial health, 2020
Exposure to inhalation anesthetics (IAs) has been associated with DNA damage as reflected in the increased frequency of micronuclei (MN) and chromosomal aberrations (CAs).
M. Neghab, Fatemeh Kargar-Shouroki, H. Mozdarani, S. Yousefinejad, H. Alipour, R. Fardid   +5 more
semanticscholar   +1 more source

Total intravenous anesthesia versus inhalation anesthesia: how do outcomes compare?

Current Opinion in Anaesthesiology, 2023
Recent findings Surgical procedures that involve general anesthesia are performed with either volatile anesthetics or propofol-based total intravenous anesthesia. Both techniques are safe and provide appropriate conditions for surgery.
M. Ramirez, T. Gan
semanticscholar   +1 more source