Results 261 to 270 of about 19,516 (323)

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

Neuroprotection, EarlyView.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai, Qing Nan, Menglu Xu, Hongbao Li   +3 more
wiley   +1 more source

Spinal cord transection repair occurs when Nestin+ cells differentiate into neurons within a taxol‐collagen‐enhanced microenvironment in mice

Neuroprotection, EarlyView.
We utilized Nestin‐CreER:tdTomato transgenic mice to directly illustrate that taxol could induce the differentiation of neural stem cells (NSCs) into neurons. This process promoted the formation of a nerve bridge connecting the two ends of the injury, ultimately resulting in the functional improvement of spinal cord injury (SCI) animals.
Caixia Fan, He Jiang, Junyan Yan, Lifang Jin, Guoquan Fu, Weiwei Xue, Lulu Zhang   +6 more
wiley   +1 more source

Anesthetics change the oral microbial composition of children and increase the abundance of the genus Haemophilus. [PDF]

Transl Pediatr
Xie D, Zhang N, Hu Y, Li Q, Yang Y, Zou Y, Lu Y, Hu W, Guo L, Li H.   +9 more
europepmc   +1 more source

Carbon Footprint of Inhaled Anesthetics – Do the Risks Outweigh the Benefits?

Liam H. Kerrick, Joseph C. Moschella
openalex   +2 more sources

Predicting Anxiety in Children Aged 2–6 During Preoperative Anesthesia Consultation—A Prospective Observational Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Preoperative Anxiety in Young Children Is Common and Can Lead to Adverse Outcomes. In Clinical Routine, Anesthesiologists Must Often Predict Anxiety Based on Limited Interaction. Aims This study aimed to evaluate the accuracy of early anxiety predictions and to identify early predictors of heightened anxiety at anesthesia induction.
Armin Sablewski, Charlotte Neitzel, Maximilian Grosser, Katarina Krebs, Anna Karstensen, Alina Balandin, Helene Selpien, Tobias Becher   +7 more
wiley   +1 more source

Effects of anesthesia on tumor perfusion and infiltration during brain tumor neurosurgery. [PDF]

Ann Med Surg (Lond)
Dhingra A, Beniwal SS, Calderón DC, Mohamed AE, Alqahtani RFM, Murtaza I, Dwivedi A.   +6 more
europepmc   +1 more source

Glucocorticoid‐Induced TNFR‐Related Ligand as a Biomarker for Diagnosis and Severity of Asthma in Children

Pediatric Discovery, EarlyView.
Our study demonstrates elevated GITRL expression in HDM‐exposed dendritic cells (in vitro), murine asthma models, and pediatric asthma patients, and reveals a direct association between GITRL levels and disease severity in children. ABSTRACT Currently, there are no reliable pediatric biomarkers for assessing the severity of asthma. Therefore, the study
Yuehan Li, Yan Li, Jinying Xiang, Yinying Ren, Mi Zhou, Fang Deng, Zhou Fu, Fengxia Ding   +7 more
wiley   +1 more source

Reducing carbon, enhancing care: the future of sustainable medicine. [PDF]

Front Pharmacol
Provenzani A, Como M, Martucci G.
europepmc   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Comparison of the effects of remimazolam and inhalational anesthesia on postoperative recovery in patients undergoing general anesthesia: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Anesth Pain Med (Seoul)
Mahendru K, Kumar A, Pandey K, Sarma R.
europepmc   +1 more source