eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha +6 more
wiley +1 more source
Comparison of the safety and efficacy of desflurane versus sevoflurane on postoperative cognitive function and early recovery quality in elderly orthopedic patients: a prospective, randomized controlled trial. [PDF]
Dong R +5 more
europepmc +1 more source
A gradient hydrogel made from human hair extracted keratins is formed via a diffusion‐mediated silver‐thiolate complexation process, driven by keratin's naturally occurring high cysteine content. This single‐step platform offers tunable gradient hydrogel properties, antibacterial activity, and supports extracellular matrix production in vitro. Enhanced
Marin Zhen Lin Yee +4 more
wiley +1 more source
Influence of sevoflurane combined with propofol anesthesia on the anesthesia effect and adverse reactions in children with acute appendicitis. [PDF]
Zhang P, Zhang J, Chen F.
europepmc +1 more source
Good Practice in Postoperative and Procedural Pain Management 2nd Edition [PDF]
CARTER, BERNIE +10 more
core
Herein, a liver‐targeted nanohybrid formulation, SGLC/DOX@AG, is developed to enhance doxorubicin delivery and reduce vascular toxicity in hepatocellular carcinoma (HCC) treatment. Incorporating an albumin–glucosamine lipid complex, the system shows potent anticancer effects and minimized side effects across in vitro, in vivo, and cancer‐on‐a‐chip ...
Hyelim Kim +11 more
wiley +1 more source
Desflurane Safety Revisited: A Pharmacovigilance Study Detecting Potential Safety Signals from FAERS Data. [PDF]
Wei W, Chen L, Ying X.
europepmc +1 more source
A laser‐assisted strategy enables the in situ formation of whitlockite coatings on bone implants through a magnesium calcium phosphate intermediate. This approach overcomes synthesis barriers, yielding bioactive surfaces that promote bone–implant integration and vascularization, offering a scalable route for next‐generation regenerative implants ...
Daehyeok Kwon +14 more
wiley +1 more source
Combined medetomidine, midazolam, and butorphanol anesthesia in mice has a central stress-relieving effect similar to that of isoflurane anesthesia. [PDF]
Yokosuka M, Osaka M, Tohei A.
europepmc +1 more source

