Results 81 to 90 of about 72,253 (289)

Inhaled drugs to reduce exacerbations in patients with chronic obstructive pulmonary disease: a network meta-analysis

BMC Medicine, 2009
Background Most patients with chronic obstructive pulmonary disease (COPD) receive inhaled long-acting bronchodilators and inhaled corticosteroids. Conventional meta-analyses established that these drugs reduce COPD exacerbations when separately compared
ter Riet Gerben, Kleijnen Jos, Bachmann Lucas M, Puhan Milo A, Kessels Alphons G   +4 more
doaj   +1 more source

Asthma referrals : a key component of asthma management that needs to be addressed [PDF]

, 2017
Peer reviewedPublisher ...
Bergen, David A, Bjermer, Leif, Martinez, Rafael, Price, David   +3 more
core   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Inhaled Corticosteroids [PDF]

, 2011
Inhalacijski kortikosteroidi (ICS) prva su linija terapije u liječenju kronične astme. Njihovo djelovanje na različite sastavnice procesa upale pridonosi smanjenju pojave simptoma, smanjenju hiperreaktivnosti dišnih putova, smanjenju potrebe za primjenom
Damir Erceg, Davor Plavec, Mirjana Turkalj   +2 more
core   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Inhaled versus systemic corticosteroids for acute exacerbations of COPD: a systematic review and meta-analysis

European Respiratory Review
This meta-analysis compares the efficacy and safety of inhaled versus systemic corticosteroids for COPD exacerbations. Following a pre-registered protocol, we appraised eligible randomised controlled trials (RCTs) according to Cochrane methodology ...
Efthymia Papadopoulou, Sulaiman Bin Safar, Ali Khalil, Jan Hansel, Ran Wang, Alexandru Corlateanu, Konstantinos Kostikas, Stavros Tryfon, Jørgen Vestbo, Alexander G. Mathioudakis   +9 more
doaj   +1 more source

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations [PDF]

, 2018
The United Kingdom National Review of Asthma Deaths (NRAD) recommends that patients who require ≥3 courses of oral corticosteroids (OCS) for exacerbations in the past year or those on British Thoracic Society (BTS) Step 4/5 treatment must be referred to ...
Barclay, Stephen, Chaudhuri, Rekha, Lee, Wai-Ting Nicola, MacBride-Stewart, Sean, McCallum, Craig, McSharry, Charles, Murray, Diane, O'Pray, Hugh, Ramparsad, Nitish, Sharma, Varun, Shepherd, Malcolm, Thomson, Neil C., Yang, Jieqiong Freda   +12 more
core   +2 more sources

Impact of empiric potassium supplementation on mortality, sudden cardiac arrest and stroke in furosemide initiators

British Journal of Clinical Pharmacology, EarlyView.
Aim A prior non‐randomized study suggests that potassium supplementation may improve survival among furosemide initiators, and a randomized trial suggests that salt substitutes containing potassium might lower stroke risk. We conducted a retrospective cohort study using health‐care data to confirm or refute these associations among new users of ...
Thanh Phuong Pham Nguyen, Sean Hennessy, Colleen M. Brensinger, Warren B. Bilker, Laura M. Dember, Todd A. Miano, Tat‐Thang Vo, Allison W. Willis, Charles E. Leonard   +8 more
wiley   +1 more source