Results 51 to 60 of about 3,797,701 (299)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Inherent Safety Assessment Technique for Separation Equipment in Preliminary Engineering Stage
Chemical Engineering Transactions, 2015 This paper highlights the development of new numerical approach for inherent safety assessment for separation process during the preliminary engineering stage of a typical petrochemical process lifecycle.
S.I. Ahmad +3 more
doaj +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Inherent Safety Development Applied to Green Processes and Energy Transition
Chemical Engineering Transactions, 2023 Agri-food wastes are annually generated in huge amounts along the whole supply chain and are distinguished for their high moisture content, biological instability, organic load, and potential environmental impact, contributing to climate changes.
Maria Bolla +2 more
doaj
Lng Regasification Terminals: Comparing the Inherent Safety Performance of Innovative Technologies
Chemical Engineering Transactions, 2010 preview not available - see full-text PDF article.
A. Tugnoli +3 more
doaj +1 more source
Reaction Path Synthesis Based on Fuzzy Evaluation in Safety, Environment and Health Impact
Chemical Engineering Transactions, 2020 To eliminate hazards during early phase of chemical process and obtain chemical reaction path with benign safety, the strategy is proposed by considering safety factors during reaction path synthesis.
Xiaoyan Sun +3 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
한국해양공학회지, 2018 An FLNG (floating liquefied natural gas) or LNG FPSO (floating production, storage and offloading) unit is a notable offshore unit with the increasing demand for LNG.
Wonwo You +3 more
doaj +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
OFISI, a novel optimizable inherent safety index based on fuzzy logic
Computers and Chemical Engineering, 2019 In our days, the concept of inherent safety is gaining popularity thanks to its ability to assess the safety level of a plant at an early design stage. Hence, safety can be considered one of the core design principles, instead of a post-design add-on. In
D. Vázquez +2 more
semanticscholar +1 more source