Results 41 to 50 of about 263,304 (259)

Research Progress in Key Thermal-hydraulic Issue of Sodium-cooled Fast Reactor

open access: yesYuanzineng kexue jishu
Sodium-cooled fast reactors are considered the preferred reactor type for fourth generation nuclear energy systems due to their high thermal efficiency, high fuel utilization efficiency, inherent safety, and unique advantages of achieving a closed fuel ...
YANG Hongyi1, XUE Xiuli1, , , ZHOU Zhiwei1, LIN Chao1, LI Hongrui2, GAO Xinzhao1, YU Xintai1, MA Xiao1, XIAO Yubai1, LUO Rui2
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Inherent Safety Assessment Technique for Separation Equipment in Preliminary Engineering Stage

open access: yesChemical Engineering Transactions, 2015
This paper highlights the development of new numerical approach for inherent safety assessment for separation process during the preliminary engineering stage of a typical petrochemical process lifecycle.
S.I. Ahmad   +3 more
doaj   +1 more source

Fusion Blanket Inherent Safety Assessment [PDF]

open access: yesFusion Technology, 1986
Fusion has significant potential safety advantages. There is a strong incentive for designing fusion plants to ensure that inherent safety will be achieved. Accordingly, both the Tokamak Power Systems Studies and MINIMARS have identified inherent safety as a design goal.
Sze, D.K., Jung, J., Cheng, E.T.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Inherent Safety Development Applied to Green Processes and Energy Transition

open access: yesChemical Engineering Transactions, 2023
Agri-food wastes are annually generated in huge amounts along the whole supply chain and are distinguished for their high moisture content, biological instability, organic load, and potential environmental impact, contributing to climate changes.
Maria Bolla   +2 more
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Lng Regasification Terminals: Comparing the Inherent Safety Performance of Innovative Technologies

open access: yesChemical Engineering Transactions, 2010
preview not available - see full-text PDF article.
A. Tugnoli   +3 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Unsteady State Inherent Safety Analysis of F22 Vaporization Node of TFE Pyrolysis Process

open access: yes工程科学与技术, 2019
Process safety analysis is important and necessary in the chemical process industries. However, a lack of a systemic methodology for inherent safety studies in an unsteady state, which causes more hazards and accidents.
Yangmei QIN   +4 more
doaj  

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