Results 51 to 60 of about 1,035,048 (296)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
ThermoBiogas has been identified as a sustainable resource of renewable and clean energy because of its social, economic, and environmental benefits.
Gerardo G. Esquivel-Patiño +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
FRAM for systemic accident analysis: a matrix representation of functional resonance [PDF]
, 2018 Due to the inherent complexity of nowadays Air Traffic Management (ATM) system, standard methods looking at an event as a linear sequence of failures might become inappropriate.
Costantino, Francesco +3 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Research Progress in Key Thermal-hydraulic Issue of Sodium-cooled Fast Reactor
Yuanzineng kexue jishuSodium-cooled fast reactors are considered the preferred reactor type for fourth generation nuclear energy systems due to their high thermal efficiency, high fuel utilization efficiency, inherent safety, and unique advantages of achieving a closed fuel ...
YANG Hongyi1, XUE Xiuli1, , , ZHOU Zhiwei1, LIN Chao1, LI Hongrui2, GAO Xinzhao1, YU Xintai1, MA Xiao1, XIAO Yubai1, LUO Rui2
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Inherent Safety Assessment Technique for Separation Equipment in Preliminary Engineering Stage
Chemical Engineering Transactions, 2015 This paper highlights the development of new numerical approach for inherent safety assessment for separation process during the preliminary engineering stage of a typical petrochemical process lifecycle.
S.I. Ahmad +3 more
doaj +1 more source
Uncertainty Analysis of the Adequacy Assessment Model of a Distributed Generation System [PDF]
, 2012 Due to the inherent aleatory uncertainties in renewable generators, the reliability/adequacy assessments of distributed generation (DG) systems have been particularly focused on the probabilistic modeling of random behaviors, given sufficient informative
Li, Yanfu, Zio, Enrico
core +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source