Results 51 to 60 of about 240,946 (255)

Potential Explosion Risk Comparison between SMR and DMR Liquefaction Processes at Conceptual Design Stage of FLNG

한국해양공학회지, 2018
An FLNG (floating liquefied natural gas) or LNG FPSO (floating production, storage and offloading) unit is a notable offshore unit with the increasing demand for LNG.
Wonwo You, Minho Chae, Jaeuk Park, Youngsub Lim   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Inherent Safety Assessment for Two Solar-based Fuels Production Processes: Methanol via CO2 Catalytic Hydrogenation and Biodiesel from Microalgal Oil

Chemical Engineering Transactions, 2020
Safety is an aspect of primary relevance in early-process design and can hardly be neglected: the consequences of accidents in chemical plants have always high impact on economics and reputation.
Mariasole Cipolletta, Valeria Casson Moreno, Valerio Cozzani   +2 more
doaj   +1 more source

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Experimental Parameter Study and Inherent Scattering of Safety Characteristics of Dusts

Chemical Engineering Transactions, 2023
Safety characteristics are widely used in industrial processes to avoid explosive atmospheres (primary explosion protection) or to mitigate the consequences of an explosion (constructive explosion protection).
Stefan H. Spitzer, Arne Krietsch, Vojtech Jankuj   +2 more
doaj  

Inherent Safety Assessment of Industrial-Scale Production of Chitosan Microbeads Modified with TiO₂ Nanoparticles. [PDF]

Biomolecules, 2021
Meramo-Hurtado S, Ceballos-Arrieta N, Cortes-Caballero J, Leon-Pulido J, Gonzalez-Quiroga A, Gonzalez-Delgado ÁD.   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source