Results 1 to 10 of about 614,400 (205)

Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

Nature Communications, 2021
22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA ...
Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Proccacia, Germano Cecere   +8 more
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Germline inherited small RNAs facilitate the clearance of untranslated maternal mRNAs in C. elegans embryos

Nature Communications, 2021
In animal embryos, maternally deposited mRNAs are degraded by several different mechanisms. Here the authors show that C. elegans embryos inherit antisense pool of small RNAs which are loaded into CSR-1 and cleave complementary maternal mRNAs.
Piergiuseppe Quarato, Meetali Singh, Eric Cornes, Blaise Li, Loan Bourdon, Florian Mueller, Celine Didier, Germano Cecere   +7 more
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SSR molecular marker developments and genetic diversity analysis of Zanthoxylum nitidum (Roxb.) DC

Scientific Reports, 2023
Zanthoxylum nitidum (Roxb.) is a commonly used traditional Chinese medicine. However, the collection and protection of wild germplasm resources of Z. nitidum are still insufficient, and there is limited research on its genetic diversity and fingerprint ...
Yanxia Zhu, Tao Ma, Yang Lin, Yude Peng, Yuan Huang, Jianping Jiang   +5 more
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Meroterpenoid Dimers from Ganoderma Mushrooms and Their Biological Activities Against Triple Negative Breast Cancer Cells

Frontiers in Chemistry, 2022
(±)-Dimercochlearlactones A−J (1–10), ten pairs of novel meroterpenoid dimers and one known spirocochlealactone A (11), were isolated from Ganoderma mushrooms.
Fu-Ying Qin, Yan-Yi Chen, Jiao-Jiao Zhang, Yong-Xian Cheng, Yong-Xian Cheng   +4 more
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Influence of Multi-Frequency Ultrasound Treatment on Conformational Characteristics of Beef Myofibrillar Proteins with Different Degrees of Doneness

Foods, 2023
This study evaluated the effect of multi-frequency sonication (20 kHz, 25 kHz, 28 kHz, 40 kHz, 50 kHz) on structural characteristics of beef myofibrillar proteins (MPs) with different degrees of doneness (Rare 52~55 °C, Medium Rare 55~60 °C, Medium 60~65
Zhaoli Zhang, Tingxuan Yang, Yang Wang, Jiarui Liu, Wangbin Shi, Haochen Hu, Yang Meng, Xiangren Meng, Ronghai He   +8 more
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Qingda Granule Attenuates Angiotensin II-Induced Blood Pressure and Inhibits Ca2+/ERK Signaling Pathway

Frontiers in Pharmacology, 2021
Objective: As a well-known traditional Chinese medicine formula prescribed by academician Ke-ji Chen, Qingda granule (QDG) lowered the blood pressure of spontaneously hypertensive rats and attenuated hypertensive cardiac remodeling and inflammation ...
Meizhu Wu, Meizhu Wu, Meizhu Wu, Xiangyan Wu, Xiangyan Wu, Xiangyan Wu, Ying Cheng, Ying Cheng, Ying Cheng, Zhiqing Shen, Zhiqing Shen, Zhiqing Shen, Xiaoping Chen, Xiaoping Chen, Xiaoping Chen, Qiurong Xie, Qiurong Xie, Qiurong Xie, Jianfeng Chu, Jianfeng Chu, Jianfeng Chu, Jiapeng Li, Liya Liu, Liya Liu, Liya Liu, Lihui Wei, Lihui Wei, Lihui Wei, Linzi Long, Linzi Long, Linzi Long, Linzi Long, Qiaoyan Cai, Qiaoyan Cai, Qiaoyan Cai, Jun Peng, Jun Peng, Jun Peng, Aling Shen, Aling Shen, Aling Shen   +40 more
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Racemic Norlignans as Diastereoisomers from Ferula sinkiangensis Resins with Antitumor and Wound-Healing Promotion Activities

Molecules, 2022
Ferulasinkins A–D (1–4), four new norlignans, were isolated from the resins of Ferula sinkiangensis, a medicinal plant of the Apiaceae family. All of them were obtained as racemic mixtures, chiral HPLC was used to produce their (+)- and (−)-antipodes ...
Ying-Shi Li, Bao-Chen Yang, Shu-Min Zheng, Yong-Xian Cheng, Hong-Hua Cui   +4 more
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Changes in Textural Quality and Water Retention of Spiced Beef under Ultrasound-Assisted Sous-Vide Cooking and Its Possible Mechanisms

Foods, 2022
The present study investigated the effects of ultrasound (28 kHz, 60 W at 71 °C for 37 min) combined with sous-vide cooking (at 71 °C for 40, 60, 80, 100, 120 min) on the textural quality, water distribution, and protein characteristics of spiced beef ...
Hengpeng Wang, Ziwu Gao, Xiuyun Guo, Sumin Gao, Danxuan Wu, Zongzhen Liu, Peng Wu, Zhicheng Xu, Xiaobo Zou, Xiangren Meng   +9 more
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Terminal Cyclohexane-Type Meroterpenoids from the Fruiting Bodies of Ganoderma cochlear

Frontiers in Chemistry, 2021
Eleven new cyclohexane-type meroterpenoids (1, 3–5, 7, 8, 11–15) and four known similar meroterpenoids (2, 6, 9, and 10) were isolated from Ganoderma cochlear.
Fu-Ying Qin, Te Xu, Yan-Peng Li, Hao-Xing Zhang, Dan Cai, Li-Zhong Liu, Yong-Xian Cheng, Yong-Xian Cheng   +7 more
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A small-molecule compound D6 overcomes EGFR-T790M-mediated resistance in non-small cell lung cancer

Communications Biology, 2021
Tang et al. propose the use of a small molecule compound D6 to treat EGFRTKI resistant tumors. The authors demonstrate potent and selective inhibition of NSCLC with T790M-mediated EGFR-TKI resistance through inhibiting HSP90-mediated protein–protein ...
Xiaolong Tang, Lizhi Cheng, Guo Li, Yong-Ming Yan, Fengting Su, Dan-Ling Huang, Shuping Zhang, Zuojun Liu, Minxian Qian, Ji Li, Yong-Xian Cheng, Baohua Liu   +11 more
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