Results 101 to 110 of about 89,530 (308)

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

open access: yesAdvanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia   +15 more
wiley   +1 more source

Constitutionally-Bounded Legal Pluralism: Reconciling Inheritance Law and Women's Rights in Indonesia

open access: yesJurnal Cakrawala Hukum
Indonesia's pluralistic legal order sustains a structural contradiction between positive inheritance law and customary (adat) traditions that systematically denies women their constitutionally guaranteed equal inheritance rights.
Devin Irwan Jinoto
doaj   +1 more source

Empowering Women: Inheritance Rights and Female Education in India [PDF]

open access: yes
This paper examines the impact of property inheritance rights on education of women. Using plausibly exogenous variation created by amendments to female inheritance laws in India, I nd that exposure to improved inheritance rights increased mean female ...
Roy, Sanchari
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu   +7 more
wiley   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

open access: yesAdvanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui   +9 more
wiley   +1 more source

The role of chinese culture and strategic orientation in enhancing competitive advantage and firm performance in Indonesian chinese family companies

open access: yesJPPI (Jurnal Penelitian Pendidikan Indonesia)
Chinese culture plays an important role in shaping the dynamics of family businesses in Indonesia, especially in the context of increasingly intense business competition.
Susan Kustiwan   +2 more
doaj   +1 more source

Damages for Wrongful Death in Alaska [PDF]

open access: yes, 1988
I den här rapporten presenteras den forskning om ledarskap inom offentliga sektorn som bedrivs vid Linköpings universitet. Kartläggningen är indelad i fem olika teman: Chefers arbete och förutsättningar Ledarskap och lärande Genus och jämställdhet ...
Ingraham, Millard F.
core   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

open access: yesAdvanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang   +4 more
wiley   +1 more source

"Laws of inheritance in Islam and Hinduism: A comparative study "

open access: yesالإيضاح, 2014
Laws of inheritance and succession exist since time immemorial in every human society. The estate of the deceased person is distributed amongst his/her legal heirs according to the laws of inheritance. Based on religions i.e.
Dr.Hussain Farooq, Hafiz Abdullah
doaj  

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