Results 101 to 110 of about 722,236 (315)

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Regression Test Case Selection &PrioritizationUsing Dependence Graph and Genetic Algorithm

, 2014
Regression testing is very important process in software maintenance. Unfortunately, it is costly and time consuming to allow for the re-execution of all test cases during regression testing.
Samaila Musa, A. B. Sultan, A. Ghani, S. Baharom   +3 more
semanticscholar   +1 more source

Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury

Advanced Science, EarlyView.
Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang, Zeli Xiang, Pengfei Yang, Ling Zhang, Jun Deng, Xiaohui Liao   +5 more
wiley   +1 more source

X‐Linked Gene Dosage and SOX2 Act as Key Roadblocks for Human Germ Cell Specification in Klinefelter Syndrome

Advanced Science, EarlyView.
Klinefelter syndrome‐derived iPSCs provide an excellent model for studying X chromosome inactivation and functions of escapee genes during human primordial germ cell‐like cells differentiation process. Downregulation of three X‐linked genes—IGSF1, CHRDL1, and USP9X—significantly enhances the efficiency of hPGCLCs.
Wenteng He, Qing Luo, Jian Zhao, Mengting Wang, Allan Zhao, Luohua Feng, Ahmed Reda, Eva Lindgren, Jan‐Bernd Stukenborg, Jiayu Chen, Qiaolin Deng   +10 more
wiley   +1 more source

Matrix genetics, part 4: cyclic changes of the genetic 8-dimensional Yin-Yang-algebras and the algebraic models of physiological cycles [PDF]

arXiv, 2008
The article continues an analysis of the genetic 8-dimensional Yin-Yang-algebra. This algebra was revealed in a course of matrix researches of structures of the genetic code and it was described in the author's articles arXiv:0803.3330 and arXiv:0805.4692. The article presents data about many kinds of cyclic permutations of elements of the genetic code
arxiv  

High fidelity epigenetic inheritance: Information theoretic model predicts $k$-threshold filling of histone modifications post replication [PDF]

arXiv, 2020
Beyond the genetic code, there is another layer of information encoded as chemical modifications on histone proteins positioned along the DNA. Maintaining these modifications is crucial for survival and identity of cells. How the information encoded in the histone marks gets inherited, given that only half the parental nucleosomes are transferred to ...
arxiv  

A Novel Gene Synthesis Platform for Designing Functional Protein Polymers

Advanced Science, EarlyView.
A new gene synthesis method consisting of rolling‐circle amplification and seamless cloning facilitates the advanced design of protein polymers with repetitive sequences. This method is more cost‐effective and user‐friendly than conventional methods. Using this method, a library of polymers with different repeat units can be easily constructed.
Toshimasa Homma, Rie Yamamoto, Lily Zuin Ping Ang, Alaa Fehaid, Mitsuhiro Ebara   +4 more
wiley   +1 more source

Revealing the Presence of a Symbolic Sequence Representing Multiple Nucleotides Based on K-Means Clustering of Oligonucleotides

Molecules, 2019
In biological systems, a few sequence differences diversify the hybridization profile of nucleotides and enable the quantitative control of cellular metabolism in a cooperative manner.
Byoungsang Lee, So Yeon Ahn, Charles Park, James J. Moon, Jung Heon Lee, Dan Luo, Soong Ho Um, Seung Won Shin   +7 more
doaj   +1 more source

Applications of Artificial Intelligence in Drug Repurposing

Advanced Science, EarlyView.
Artificial intelligence algorithms are transforming drug repurposing by revealing new therapeutic targets and mechanisms. This review highlights the integration of AI frameworks, multimodal datasets, and advanced optimization methods, accelerating the discovery of new indications for existing drugs.
Zhaoman Wan, Xinran Sun, Yi Li, Tianyao Chu, Xueyu Hao, Yang Cao, Peng Zhang   +6 more
wiley   +1 more source

Modelling interactions between waves and diffused interfaces

International Journal for Numerical Methods in Fluids, Volume 95, Issue 2, Page 215-241, February 2023., 2023
When simulating multiphase compressible flows using the diffuse‐interface methods, important issues arise during the interaction of waves with diffused interfaces. A solution is to use a pressure‐disequilibrium model with finite, instead of infinite, pressure‐relaxation rate.
Kevin Schmidmayer, Joris Cazé, Fabien Petitpas, Éric Daniel, Nicolas Favrie   +4 more
wiley   +1 more source