Results 141 to 150 of about 72,058 (269)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Antagonistic histone post-translational modifications improve the fidelity of epigenetic inheritance - a Bayesian perspective. [PDF]

Epigenetics Chromatin
Prabhu BNB, Soni AN, Pillai SRB, Ramakrishnan N.   +3 more
europepmc   +1 more source

Semi‐Active Movable Shear Keys for Seismic Response Control of Bridges

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT The size of the joint gaps plays a significant role in the dynamic performance of bridges. This has recently motivated the consideration of movable shear keys (MSKs), pioneered by the corresponding author, to enhance bridge performance by changing the bridge support/boundary conditions.
B. Neethu, Ioannis Mikes, Agathoklis Giaralis, Andreas Kappos   +3 more
wiley   +1 more source

Molecular Studies of <i>TCF4</i> Gene and Correlation with Late-Onset Fuchs Endothelial Corneal Dystrophy in the Greek Population: A Novel Cost-Effective Diagnostic Algorithm. [PDF]

Int J Mol Sci
Petri N, Margoni A, Droutsas K, Diamantopoulou A, Kappos N, Papavassiliou AG, Moschos MM, Kroupis C.   +7 more
europepmc   +1 more source

Affective Dimensions in Maternal Voice During Child Feeding in Mothers With and Without Eating Disorder History—Findings From a Machine Learning Analysis of Speech Data

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Eating disorder (ED) history may impact mother‐child communication during mealtimes and contribute to transgenerational transmission of ED. This study employed machine learning (ML) to identify speech characteristics during mother‐child feeding interactions, aiming for investigating whether vocalised affective characteristics differ ...
Jana Katharina Throm, Manuel Milling, Andreas Triantafyllopoulos, Alexander Kathan, Annica Franziska Dörsam, Johanna Löchner, Björn Schuller, Katrin Elisabeth Giel   +7 more
wiley   +1 more source

geneEX: An Integrated Phenotype-Driven Algorithm for Rapid Identification of Causative Variants in Monogenic Disorders. [PDF]

Mol Genet Genomic Med
Zhang J, Liu D, Chen M, Fang Y, Dai K, Zhu X, Xu Q, Hou M, Wang L, Wang J, Zhang J, Liang B, Teng X.   +12 more
europepmc   +1 more source

Advancing Food Safety Through Artificial Intelligence: A Detailed Review of Monitoring and Detection Technologies

Food Safety and Health, EarlyView.
Artificial intelligence (AI) is revolutionizing food safety by enabling rapid detection, real‐time monitoring, and enhanced traceability. This review highlights recent advances, applications, and future directions for AI‐driven technologies in safeguarding the global food supply.
Anju Kanicheril Ambikalekshmi, Poojitha Pushparaj, Elsa Cherian, Rosamma Rajan, Lakshmi Mohan   +4 more
wiley   +1 more source

Clinical use of whole-genome sequencing in children with developmental delay or intellectual disability. [PDF]

BMC Med Genomics
Xu J, Xu Y, Su W, Chen L, Wang Y, Li H.
europepmc   +1 more source

The impact of known breast cancer polygenes on critical illness insurance [PDF]

, 2015
Adams, Craig, Donnelly, Catherine, Macdonald, Angus Smith   +2 more
core   +1 more source

From Genomic Fossils to Functional Elements: The Evolving Story of Pseudogenes

Advanced Genetics, EarlyView.
This review begins with an introduction, summarizing the research background in pseudogene studies. It then contains three aspects: identification of pseudogenes, detailing their classification and features in metazoan genomes; functional pseudogenes, introducing their reactivation and regulation mechanisms; and pseudogenes’ contribution to species ...
Mengyao Sun, Yanni Ma, Jia Yu
wiley   +1 more source