Results 181 to 190 of about 13,796 (248)

HLA‐A*11:01 Identifies Patients at Risk for Persistent Viraemia and Advanced Fibrosis in HDV Infection

Alimentary Pharmacology &Therapeutics, EarlyView.
The HLA‐A*11:01 allele is associated with persistent viraemia and advanced liver fibrosis in HDV infection. HLA‐A*11:01 carriers exhibit a reduced T‐cell repertoire, suggesting a narrower T‐cell response to the infection. ABSTRACT Background Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, with highly heterogeneous ...
Maria Francesca Cortese, Adriana Palom, Ariadna Rando Segura, Francesc Rudilla, Emma Enrich Rande, Arnau Puig Lopez, David Tabernero Caellas, Judit Vico Romero, Juan Carlos Ruiz‐Cobo, Mar Riveiro‐Barciela, Maria José Herrero, Maria Buti   +11 more
wiley   +1 more source

Asymptomatic thrombocytopenia in Akitas: a prospective cross-sectional study of platelet characteristics in an Eastern Australian population. [PDF]

Aust Vet J
Bool JD, Jaensch SM, Collins D, Thrift E.   +3 more
europepmc   +1 more source

Inherited Thrombocytopenia with a Different Type of Gene Mutation: A Brief Literature Review and Two Case Studies. [PDF]

Iran J Pediatr, 2016
Arzanian MT.
europepmc   +1 more source

Carriage of the Laboratory of Genetics and Physiology Protein 2 Q425R Variant Reduces Liver Disease Severity in European Patients With Chronic Hepatitis Delta

Alimentary Pharmacology &Therapeutics, EarlyView.
In patients with chronic hepatitis Delta, the LGP2 Q425R variant (rs2074158 CC/CT genotypes), associated with an enhanced interferon response in vitro, becomes progressively less frequent as liver disease advances from no cirrhosis to cirrhosis, and to cirrhosis with progressive increase of portal hypertension evaluated by thrombocytopenia.
Sara Cmet, Elisabetta Degasperi, Annarosa Cussigh, Elisabetta Fontanini, Maria Paola Anolli, Floriana Facchetti, Riccardo Perbellini, Dana Sambarino, Sara Uceda Renteria, Mariapaola Callegaro, Davide Bitetto, Elisa Fumolo, Ezio Fornasiere, Elena Garlatti Costa, Edmondo Falleti, Pietro Lampertico, Pierluigi Toniutto   +16 more
wiley   +1 more source

Thrombotic microangiopathy-like acute kidney injury revealing a germline GATA1 mutation in a child with inherited cytopenia. [PDF]

Pediatr Nephrol
Gohary AE, Youssef DM, Hanna D, Gehad MH.   +3 more
europepmc   +1 more source

Review Article: Fibrosis‐4 Index in Steatotic Liver Disease—Past, Present and Future

Alimentary Pharmacology &Therapeutics, EarlyView.
FIB‐4 remains an inexpensive, scalable first‐line triage tool for excluding advanced fibrosis and identifying patients who need second‐line assessment, but it should not be used as a stand‐alone diagnostic or treatment‐selection test. Sequential testing and longitudinal FIB‐4 trajectories may improve risk stratification and prognosis.
Kriti Soni, Vinay Jahagirdar, Omar Albhaisi, Richard K. Sterling, Juan Pablo Arab, Hanna Blaney, Luis Antonio Díaz   +6 more
wiley   +1 more source

Curtailing the Path From Epistaxis to Genetics: The Diagnostic Value of Detailed Medical History in Hereditary Macrothrombocytopenia. [PDF]

Cureus
Ruzman L, Köpcke E, Kranjcec I.
europepmc   +1 more source

Hypertensive Disorders in Pregnancy: A Comparative Analysis of Clinical Guidelines Across Six High‐Income Countries

Birth, EarlyView.
ABSTRACT Background Women in the United States (U.S.) experience higher maternal morbidity and mortality than other high‐income countries, with hypertensive disorders of pregnancy (HDP) among the most common, preventable contributors. Despite evidence supporting pharmacologic intervention, American College of Obstetricians and Gynecologists (ACOG ...
Kortney Floyd James, Alyssa A. Portes, Kandice A. Kapinos, Lucinda Canty, Gabriela Alvarado, Karen A. Scott   +5 more
wiley   +1 more source

Case Report: Wolman disease caused by LIPA variants in two Chinese infants and a focused literature synthesis. [PDF]

Front Pediatr
Zhang L, Yu Q, Ge X, Xie X.
europepmc   +1 more source

A polygenic etiology for inherited thrombocytopenias of unknown origin. [PDF]

Hemasphere
Isidori F, Melazzini F, Santonastaso F, Marconi C, Bozzi V, Barozzi S, Mattiaccio A, Giangregorio T, Iovino E, Palumbo G, Sidore C, Pirastu N, Gialluisi A, Costanzo S, Iacoviello L, Soranzo N, Seri M, Pecci A, Pippucci T.   +18 more
europepmc   +1 more source