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Obstetrics and Gynecology Clinics of North America, 2006
Many inherited thrombophilias have been detected and the pathophysiologic insight has increased tremendously during the last decades. Despite, however, the overwhelming observational evidence on the association between inherited thrombophilia and several women's health issues, including VTE, thus far the implications for clinical practice are uncertain.
Coppens, Michiel +2 more
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Many inherited thrombophilias have been detected and the pathophysiologic insight has increased tremendously during the last decades. Despite, however, the overwhelming observational evidence on the association between inherited thrombophilia and several women's health issues, including VTE, thus far the implications for clinical practice are uncertain.
Coppens, Michiel +2 more
openaire +3 more sources
High prevalence of inherited thrombophilia in ‘presumed peri‐neonatal’ ischemic stroke
European Journal of Haematology, 2008 The aim of this study was to assess the prevalence of inherited thrombophilia in 'peri-neonatal arterial ischemic stroke' (AIS), and its possible correlation with type of stroke and long-term neurological outcome. A cohort of twenty-four infants affected
Agnese Suppiej +2 more
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Clinics in Laboratory Medicine, 2013 The association between inherited thrombophilia and deep vein thrombosis is well established. Adverse pregnancy outcomes, sometimes called placenta-mediated complications, have been attributed to excessive thrombosis and inflammation at the ...
Nazli Hossain, Michael J. Paidas
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Inherited and Acquired Thrombophilias
Reproductive Sciences, 2014Thrombophilias represent an evolving story that continues to stir controversy for care providers and obstetrical patients. The predominant thrombophilic mutations include the factor V Leiden mutation, prothrombin gene mutation G20210A, methylene tetrahydrafolate reductase C667T, and deficiencies of the natural anticoagulants proteins C and S, and ...
Rambaldi MP +3 more
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Inherited thrombophilia and pregnancy
Current Opinion in Obstetrics and Gynaecology, 1998Inherited thrombophilia is associated with an increased risk of thrombosis. Classically it consists of protein C and protein S deficiency, activated protein C resistance and antithrombin III deficiency. In pregnancy, in addition to thrombosis, inherited thrombophilia is associated with poor obstetric outcome, including recurrent miscarriage, late fetal
J, Girling, M, de Swiet
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Inherited Thrombophilia and the Eye
Seminars in Ophthalmology, 2008Inherited thrombophilic disorders are a well-recognized risk factor for systemic thromboembolism. These disorders include deficiencies of anticoagulant proteins such as protein C, protein S, and antithrombin III, abnormalities of factor V and prothrombin resulting from genetic mutations, and hyperhomocysteinemia.
Cheryl, Czerlanis +2 more
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Inherited Thrombophilia in Children
Current Problems in Pediatric and Adolescent Health Care, 2013Thrombosis in children has multiple etiologies, including inherited disorders such as factor V Leiden mutation, prothrombin 20210A mutation, and deficiencies in protein C, S, or antithrombin. Epidemiology of the disorders varies, as does the risk of thrombosis. Venous thromboembolism is the typical presentation.
Michael, Silvey, Shannon L, Carpenter
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Inherited thrombophilia and stillbirth
Seminars in Perinatology, 2002Thrombophilias are inherited or acquired conditions that predispose individuals to thromboembolism. New inherited thrombophilias are recognized each year. Some, but not all, studies have found an association between inherited thrombophilias and adverse pregnancy outcomes, including fetal loss.
George R, Saade, Claire, McLintock
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Inherited Thrombophilia and Pregnancy Loss
Thrombosis and Haemostasis, 1999IntroductionA successful pregnancy is dependent on the development of adequate placental circulation. Abnormalities of placental vasculature may result in a number of gestational pathologies, including first and second trimester miscarriages, intrauterine growth retardation (IUGR), intrauterine fetal death (IUFD), placental abruption, and preeclampsia ...
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The molecular mechanisms of inherited thrombophilia
Zeitschrift für Kardiologie, 2000Venous Thromboembolism develops as the result of multiple interactions between non-genetic and genetic risk factors. The most important non-genetic risk factors are age, tissue damage, oral contraception, pregnancy, obesity and lack of physical activity. Inborn factors predisposing to thrombosis are present in the majority of patients.
März, Winfried +2 more
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