Results 161 to 170 of about 194,689 (201)
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Inherited Thrombophilia Genes in Minorities
Genetic Testing, 1999Mutations in several genes have recently been identified which predispose to thrombosis, specifically Factor V G1691A (Factor V Leiden), Prothrombin G20210A, and Methylene tetrahydrofolate reductase (MTHFR) C677T. The prevalence of these genes in European populations has been studied, but there is little data on their prevalence in minorities.
R, Mack +3 more
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Hunting for the mutation in inherited thrombophilia
Blood Coagulation & Fibrinolysis, 2004Mutation detection in inherited thrombophilia remains largely confined to the research laboratory. However, there are specific situations when investigating the genetic defect causing thrombophilia can provide additional useful clinical information. This review discusses the value of genetic analysis in the common inherited thrombophilias.
Keith, Gomez, Michael A, Laffan
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Recenti progressi in medicina, 2005
Inherited thrombophilia can be defined as a genetically determined predisposition to develop thromboembolic complications. Inherited prothrombotic risk factors include antithrombin deficiency, protein C and protein S deficiencies, activated protein C resistance due to Leiden factor V mutation, inherited hyperhomocysteinemia, prothrombin G20210A variant,
Massimo, Franchini, Dino, Veneri
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Inherited thrombophilia can be defined as a genetically determined predisposition to develop thromboembolic complications. Inherited prothrombotic risk factors include antithrombin deficiency, protein C and protein S deficiencies, activated protein C resistance due to Leiden factor V mutation, inherited hyperhomocysteinemia, prothrombin G20210A variant,
Massimo, Franchini, Dino, Veneri
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Perinatal Aspects of Inherited Thrombophilia
Seminars in Thrombosis and Hemostasis, 1999The identified main causes of inherited thrombophilia are deficiencies of antithrombin, protein C and protein S, activated protein C (APC) resistance and the factor V Leiden mutation, mutant factor II, and inherited hyperhomocysteinemia. In women from symptomatic families these defects may be associated with an increased risk of venous thrombosis in ...
J, Bonnar, R, Green, L, Norris
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The molecular mechanisms of inherited thrombophilia
Zeitschrift für Kardiologie, 2000Venous Thromboembolism develops as the result of multiple interactions between non-genetic and genetic risk factors. The most important non-genetic risk factors are age, tissue damage, oral contraception, pregnancy, obesity and lack of physical activity. Inborn factors predisposing to thrombosis are present in the majority of patients.
März, Winfried +2 more
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Management of inherited thrombophilia in pregnancy
Current Opinion in Endocrinology, Diabetes & Obesity, 2009This review summarizes the currently available data concerning risk and management of venous thromboembolism in pregnant women with inherited thrombophilia.Pregnancy is a hypercoagulable state, and inherited thrombophilia increases this risk further.
Annemarie E, Fogerty, Jean M, Connors
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The Molecular Basis of Inherited Thrombophilia
Vox Sanguinis, 2000SummaryEven though it has been known for centuries that inherited defects of blood coagulation cause lifelong bleeding disorders. the existence of the counterpart, inherited thrombotic disorders, has been appreciated for only a few decades. Inherited thrombophilia can be defined as a genetically determined tendency to venous thromboembolism which ...
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Genetic counseling for inherited thrombophilias
Journal of Thrombosis and Thrombolysis, 2007Genetic testing for inherited thrombophilia, including mutation analysis for factor V Leiden and prothrombin G20210A, is commonly performed. Yet, tests for inherited thrombophilia are frequently ordered inappropriately, and without proper counseling about the risks, benefits and limitations of testing.
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Inherited thrombophilia and venous thromboembolism
Best Practice & Research Clinical Obstetrics & Gynaecology, 2003Pulmonary thromboembolism (PTE) is the major cause of maternal death in the UK. Underlying PTE is the problem of deep venous thrombosis (DVT). Inherited thrombophilia will be found in about 50% of women with a personal history of venous thromboembolism (VTE), and screening for thrombophilia should be considered in women with a personal or family ...
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Thrombophilia can be defined as laboratory abnormalities, usually in the coagulation system, that result in a hypercoagulable state and thus predispose to thrombosis. These abnormalities may be acquired or inherited. The most clearly established form of acquired thrombophilia is the antiphospholipid anti- body syndrome.
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