Results 171 to 180 of about 6,414 (212)
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Sex, thrombosis and inherited thrombophilia
Blood Reviews, 2014The incidence of venous thromboembolism (VTE) is two-fold higher in women than in men during reproductive age, which is likely explained by the use of hormonal contraceptives and by pregnancy in this phase of life. After adjustment for these factors, men have a two-fold higher risk of developing a first VTE compared with women, which is in line with ...
Suzanne M, Bleker +2 more
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Inherited thrombophilias and anticoagulation in pregnancy
Best Practice & Research Clinical Obstetrics & Gynaecology, 2003Thromboprophylaxis, primary or secondary, should be considered in selected pregnant women with inherited thrombophilias; such women may be divided into high-, medium- and low-risk categories on the basis of the specific thrombophilic defect and any personal or family history of venous thromboembolism (VTE).
Louise, Bowles, Hannah, Cohen
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Inherited Thrombophilia Genes in Minorities
Genetic Testing, 1999Mutations in several genes have recently been identified which predispose to thrombosis, specifically Factor V G1691A (Factor V Leiden), Prothrombin G20210A, and Methylene tetrahydrofolate reductase (MTHFR) C677T. The prevalence of these genes in European populations has been studied, but there is little data on their prevalence in minorities.
R, Mack +3 more
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Hunting for the mutation in inherited thrombophilia
Blood Coagulation & Fibrinolysis, 2004Mutation detection in inherited thrombophilia remains largely confined to the research laboratory. However, there are specific situations when investigating the genetic defect causing thrombophilia can provide additional useful clinical information. This review discusses the value of genetic analysis in the common inherited thrombophilias.
Keith, Gomez, Michael A, Laffan
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Recenti progressi in medicina, 2005
Inherited thrombophilia can be defined as a genetically determined predisposition to develop thromboembolic complications. Inherited prothrombotic risk factors include antithrombin deficiency, protein C and protein S deficiencies, activated protein C resistance due to Leiden factor V mutation, inherited hyperhomocysteinemia, prothrombin G20210A variant,
Massimo, Franchini, Dino, Veneri
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Inherited thrombophilia can be defined as a genetically determined predisposition to develop thromboembolic complications. Inherited prothrombotic risk factors include antithrombin deficiency, protein C and protein S deficiencies, activated protein C resistance due to Leiden factor V mutation, inherited hyperhomocysteinemia, prothrombin G20210A variant,
Massimo, Franchini, Dino, Veneri
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Management of inherited thrombophilia in pregnancy
Current Opinion in Endocrinology, Diabetes & Obesity, 2009This review summarizes the currently available data concerning risk and management of venous thromboembolism in pregnant women with inherited thrombophilia.Pregnancy is a hypercoagulable state, and inherited thrombophilia increases this risk further.
Annemarie E, Fogerty, Jean M, Connors
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Perinatal Aspects of Inherited Thrombophilia
Seminars in Thrombosis and Hemostasis, 1999The identified main causes of inherited thrombophilia are deficiencies of antithrombin, protein C and protein S, activated protein C (APC) resistance and the factor V Leiden mutation, mutant factor II, and inherited hyperhomocysteinemia. In women from symptomatic families these defects may be associated with an increased risk of venous thrombosis in ...
J, Bonnar, R, Green, L, Norris
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The Molecular Basis of Inherited Thrombophilia
Vox Sanguinis, 2000SummaryEven though it has been known for centuries that inherited defects of blood coagulation cause lifelong bleeding disorders. the existence of the counterpart, inherited thrombotic disorders, has been appreciated for only a few decades. Inherited thrombophilia can be defined as a genetically determined tendency to venous thromboembolism which ...
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Inherited thrombophilia and fetal loss
Current Opinion in Hematology, 2000Acquired thrombophilia is a well-established cause of pregnancy loss. Increasing numbers of recent observations suggest that inherited thrombophilia is not only associated with gestational thromboembolism but is also a major cause of fetal loss. This review focuses on association of fetal loss with inherited thrombophilias, including dysfibrinogenemia ...
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Inherited thrombophilia and venous thromboembolism
Best Practice & Research Clinical Obstetrics & Gynaecology, 2003Pulmonary thromboembolism (PTE) is the major cause of maternal death in the UK. Underlying PTE is the problem of deep venous thrombosis (DVT). Inherited thrombophilia will be found in about 50% of women with a personal history of venous thromboembolism (VTE), and screening for thrombophilia should be considered in women with a personal or family ...
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