Results 221 to 230 of about 4,033,279 (373)

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

Science, 2009
K. Olive, Michael A. Jacobetz, Christian J. Davidson, A. Gopinathan, D. McIntyre, D. Honess, B. Madhu, M. Goldgraben, Meredith E. Caldwell, D. Allard, K. Frese, G. DeNicola, C. Feig, C. Combs, Stephen P. Winter, Heather Ireland-Zecchini, S. Reichelt, W. Howat, A.-L. Chang, M. Dhara, Lifu Wang, F. Rückert, R. Grützmann, C. Pilarsky, K. Izeradjene, S. Hingorani, Pearl S Huang, S. Davies, W. Plunkett, M. Egorin, R. Hruban, Nigel Whitebread, Karen McGovern, J. Adams, C. Iacobuzio-Donahue, J. Griffiths, D. Tuveson   +36 more
semanticscholar   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

THE INHIBITION OF AUTOLYSIS BY ALCOHOL

, 1914
H. Gideon Wells, George T. Caldwell
openalex   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, Volume 19, Issue 5, Page 1471-1492, May 2025.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Decoding the selective chemical modulation of CYP3A4. [PDF]

Nat Commun
Wang J, Nithianantham S, Chai SC, Jung YH, Yang L, Ong HW, Li Y, Zhang Y, Miller DJ, Chen T.   +9 more
europepmc   +1 more source

IN VITRO SWELLING OF THE KITTEN RETINA INDUCED BY SODIUM FLUORIDE INHIBITION [PDF]

, 1959
Clive N. Graymore
openalex   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Liquidambaric acid as a non-competitive α-glucosidase inhibitor: multi-level evidence from enzyme kinetics, molecular docking, molecular dynamics simulations, and a <i>Drosophila</i> hyperglycaemic model. [PDF]

J Enzyme Inhib Med Chem
Jia L, Liu Y, Fu B, Tian Y, Meng X.
europepmc   +1 more source

INHIBITION OF GUANASE IN VITRO BY VARIOUS PTERIDINE COMPOUNDS

, 1953
L.S. Dietrich, Daniel M. Shapiro
openalex   +1 more source

Effect of Chemical Structure on the Growth Inhibition of Plants with Some Acid Analogs of 2-Mercaptobenzimidazole. [PDF]

, 1957
Theodore L. Rebstock, Charles D. Ball, C. L. Hamner, Harold M. Sell   +3 more
openalex   +1 more source