Results 21 to 30 of about 3,447,958 (308)
Hereditary Cancer in Clinical Practice, 2015 بوليميرازات بولي (ADP - ريبوز)، التي يتم اختصارها باسم PARPs، هي مجموعة من البروتينات المألوفة التي تلعب دورًا مركزيًا في إصلاح الحمض النووي باستخدام مسار إصلاح استئصال القاعدة (BER). هناك حوالي 17 بروتينًا في هذه العائلة منها PARPs النووية الأولية هي PARP -1 و PARP -2 و PARP -3 و tankyrases 1 و 2 (PARP -5a و -5b).
Maheen Anwar +2 more
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Teknika, 2014 Berdasarkan berbagai penelitian, kulit manggis memiliki potensi yang baik sebagai inhibitor korosi Tujuan dari penelitian ini adalah untuk mengetahui efisiensi ekstrak inhibitor kulit manggis pada baja lunak dalam larutan asam sulfat.
Marta Pramudita +2 more
doaj +1 more source
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC inhibitors has attracted increasing ...
Mazen Aseeri +5 more
doaj +1 more source
Second-line antiretroviral therapy in resource-limited settings: the experience of Médecins Sans Frontières [PDF]
, 2008 OBJECTIVES: To describe the use of second-line protease-inhibitor regimens in Médecins Sans Frontières HIV programmes, and determine switch rates, clinical outcomes, and factors associated with survival.
Alexandra Calmy +24 more
core +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Schistosoma mansoni is an intestinal parasite with one β-class carbonic anhydrase, SmaBCA. We report the sequence enhancing, production, catalytic activity, and inhibition results of the recombinant SmaBCA. It showed significant catalytic activity on CO2
Susanna Haapanen +5 more
doaj +1 more source
Kinetic and thermodynamic analysis of leech-derived tryptase inhibitor interaction with bovine tryptase and bovine trypsin [PDF]
, 2000 The interaction of leech-derived tryptase inhibitor (LDTI) with bovine liver capsule tryptase (BLCT) and bovine trypsin has been studied using both thermodynamic and kinetic approaches.
Auerswald E.A. +6 more
core +1 more source
Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Structural tailoring of the flavone framework (position 7) via organopalladium-catalyzed C–C bond formation was attempted in this study. The impact of substituents with varied electronic effects (phenyl ring, position 2 of the benzopyran scaffold) on the
Sachin Sharma +11 more
doaj +1 more source
Antioxidants, 2022 Acute myeloid leukemia (AML) cells harbor elevated levels of reactive oxygen species (ROS), which promote cell proliferation and cause oxidative stress. Therefore, the inhibition of ROS formation or elevation beyond a toxic level have been considered as ...
Muhammed Burak Demircan +6 more
doaj +1 more source
In vivo E2F reporting reveals efficacious schedules of MEK1/2–CDK4/6 targeting and mTOR–s6 resistance mechanisms [PDF]
, 2018 Targeting cyclin-dependent kinases 4/6 (CDK4/6) represents a therapeutic option in combination with BRAF inhibitor and/or MEK inhibitor (MEKi) in melanoma; however, continuous dosing elicits toxicities in patients. Using quantitative and temporal in vivo
Aplin, Andrew E. +14 more
core +1 more source
Farnesyltransferase inhibitors
Seminars in Oncology, 2001 The targeting of molecular abnormalities in neoplasms may provide an opportunity to improve the selectivity of cancer therapy. Ras mutations are a common genetic event in human cancers. Other genetic changes in tumors can signal through ras-dependent pathways as well.
Hahn, S, Bernhard, E, Mckenna, W
openaire +3 more sources