Results 21 to 30 of about 7,182,372 (402)

Syk inhibitors

open access: yesJapanese Journal of Clinical Immunology, 2013
Non-receptor type of protein-tyrosine kinase Syk (spleen tyrosine kinase) was isolated in University of Fukui in 1991. Syk is most highly expressed by haemopoietic cells and known to play crucial roles in the signal transduction through various immunoreceptors of the adaptive immune response.
Kazuyasu, Chihara   +4 more
openaire   +3 more sources

Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster [PDF]

open access: yes, 2004
BACKGROUND: Pancreatic cholesterol esterase has three proposed functions in the intestine: 1) to control the bioavailability of cholesterol from dietary cholesterol esters; 2) to contribute to incorporation of cholesterol into mixed micelles; and 3) to ...
Contos, Linda M   +4 more
core   +2 more sources

Identification of Modulators of HIV-1 Proviral Transcription from a Library of FDA-Approved Pharmaceuticals

open access: yesViruses, 2020
Human immunodeficiency virus 1 (HIV-1) is the most prevalent human retrovirus. Recent data show that 34 million people are living with HIV-1 worldwide.
Gavin C. Sampey   +6 more
doaj   +1 more source

Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling [PDF]

open access: yes, 2019
The growth factor bone morphogenetic protein 2 (BMP2) plays an important role in bone development and repair. Despite the positive effects of BMP2 in fracture healing, its use is associated with negative side effects and poor cost effectiveness, partly ...
Bormann, Nicole   +5 more
core   +1 more source

The role and action mechanism of inhibitors in solutions for etching steel

open access: yesZaštita Materijala, 2015
Acid etching has a major task, regardless of which acid is used, to cancel all corrosion products from objects before it starts to erode base material.
Bosiljka Ljubičić, Saša Mićin
doaj   +1 more source

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

open access: yesFrontiers in Chemistry, 2022
The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2.
Dale J. Calleja   +25 more
doaj   +1 more source

PARP inhibitors [PDF]

open access: yesHereditary Cancer in Clinical Practice, 2015
بوليميرازات بولي (ADP - ريبوز)، التي يتم اختصارها باسم PARPs، هي مجموعة من البروتينات المألوفة التي تلعب دورًا مركزيًا في إصلاح الحمض النووي باستخدام مسار إصلاح استئصال القاعدة (BER). هناك حوالي 17 بروتينًا في هذه العائلة منها PARPs النووية الأولية هي PARP -1 و PARP -2 و PARP -3 و tankyrases 1 و 2 (PARP -5a و -5b).
Maheen Anwar   +2 more
openaire   +2 more sources

The roles of p38mAPK and caspase-3 in dads-induced apoptosis in human HepG2 cells [PDF]

open access: yesArchives of Biological Sciences, 2010
The roles of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells were investigated. After the human HepG2 cells were treated with DADS, the cell viability, apoptosis and the activity changes of p38MAPK and caspase-3 were measured.
Chunxiao Ji, Heng Ma, Ren Fenglian
doaj   +1 more source

Ekstrak Kulit Manggis (Garcinia Mangostana L) Sebagai Inhibitor Korosi Baja Lunak (Mild Steel) Dalam Larutan H2SO4 1 M

open access: yesTeknika, 2014
Berdasarkan berbagai penelitian, kulit manggis memiliki potensi yang baik sebagai inhibitor korosi Tujuan dari penelitian ini adalah untuk mengetahui efisiensi ekstrak inhibitor kulit manggis pada baja lunak dalam larutan asam sulfat.
Marta Pramudita   +2 more
doaj   +1 more source

Second-line antiretroviral therapy in resource-limited settings: the experience of Médecins Sans Frontières [PDF]

open access: yes, 2008
OBJECTIVES: To describe the use of second-line protease-inhibitor regimens in Médecins Sans Frontières HIV programmes, and determine switch rates, clinical outcomes, and factors associated with survival.
Alexandra Calmy   +24 more
core   +2 more sources

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