Results 31 to 40 of about 3,476,202 (307)
Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors
Molecules, 2023 Sulfonamides remain an important class of drugs, especially because of their inhibitory effects on carbonic anhydrases. Herein, we have synthesized several sulfonamides and tested them for their inhibitory activity against carbonic anhydrases hCA I, hCA ...
Toni C. Denner +4 more
doaj +1 more source
Kinetic and thermodynamic analysis of leech-derived tryptase inhibitor interaction with bovine tryptase and bovine trypsin [PDF]
, 2000 The interaction of leech-derived tryptase inhibitor (LDTI) with bovine liver capsule tryptase (BLCT) and bovine trypsin has been studied using both thermodynamic and kinetic approaches.
Auerswald E.A. +6 more
core +1 more source
Molecules, 2022 In blood coagulation, circulating platelets and coagulation factors are crucial for the primary process because thrombi are generated by fibrin clotting with fibrinogen, thrombin, FXIIIa, and platelet activation.
Jun-Hui Choi, Seung Kim
doaj +1 more source
Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]
, 2011 Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines +5 more
core +2 more sources
Cell Death & Differentiation, 1999 Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
P G, Ekert, J, Silke, D L, Vaux
openaire +2 more sources
Известия высших учебных заведений: Нефть и газ, 2020 The article discusses the results of a study on the selection of wax inhibitors that can be used at the Kondinskoye oil field during transportation and dehydration of the emulsion.Asphaltene precipitation is one of the most serious issues in oil ...
E. N. Skvortsova, O. P. Deryugina
doaj +1 more source
Molecules, 2022 Cancer is a multifactorial disorder caused by several aberrations in gene expression that generate a homeostatic imbalance between cell division and death [...]
Alessandra Ammazzalorso +1 more
openaire +3 more sources
Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. [PDF]
, 2016 Inhibitors of BRAFV600E kinase are currently under investigations in preclinical and clinical studies involving BRAFV600E glioma. Studies demonstrated clinical response to such individualized therapy in the majority of patients whereas in some patients ...
Berger, Mitchel S +12 more
core +1 more source
Research towards selective inhibition of the CLK3 kinase
Beilstein Journal of Organic ChemistryThe cdc2-like kinases (CLKs), are a family of kinases that attracted recently the interest of scientists due to their significant biological roles, in particular in the regulation of the mRNA splicing process. Among the four isoforms of CLKs, CLK3 is the
Vinay Kumar Singh +9 more
doaj +1 more source
Small molecule Mcl-1 inhibitor for triple negative breast cancer therapy
Frontiers in Cell and Developmental BiologyApoptosis is an evolutionarily conserved cell death pathway that plays a crucial role in maintaining tissue homeostasis, orchestrating organismal development, and eliminating damaged cells. Dysregulation of apoptosis can contribute to the pathogenesis of
Shengli Dong +2 more
doaj +1 more source