Results 31 to 40 of about 2,020,141 (269)
Bioorganic & Medicinal Chemistry Letters, 2015 Targeting macromolecular interface is a general mechanism by which natural products inactivate macromolecular complexes by stabilizing normally transient intermediates. Demonstrating interfacial inhibition mechanism ultimately relies on the resolution of drug-macromolecule structures.
Yves, Pommier +2 more
openaire +3 more sources
Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors
Molecules, 2023 Sulfonamides remain an important class of drugs, especially because of their inhibitory effects on carbonic anhydrases. Herein, we have synthesized several sulfonamides and tested them for their inhibitory activity against carbonic anhydrases hCA I, hCA ...
Toni C. Denner +4 more
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Molecules, 2022 In blood coagulation, circulating platelets and coagulation factors are crucial for the primary process because thrombi are generated by fibrin clotting with fibrinogen, thrombin, FXIIIa, and platelet activation.
Jun-Hui Choi, Seung Kim
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Известия высших учебных заведений: Нефть и газ, 2020 The article discusses the results of a study on the selection of wax inhibitors that can be used at the Kondinskoye oil field during transportation and dehydration of the emulsion.Asphaltene precipitation is one of the most serious issues in oil ...
E. N. Skvortsova, O. P. Deryugina
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Research towards selective inhibition of the CLK3 kinase
Beilstein Journal of Organic ChemistryThe cdc2-like kinases (CLKs), are a family of kinases that attracted recently the interest of scientists due to their significant biological roles, in particular in the regulation of the mRNA splicing process. Among the four isoforms of CLKs, CLK3 is the
Vinay Kumar Singh +9 more
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Small molecule Mcl-1 inhibitor for triple negative breast cancer therapy
Frontiers in Cell and Developmental BiologyApoptosis is an evolutionarily conserved cell death pathway that plays a crucial role in maintaining tissue homeostasis, orchestrating organismal development, and eliminating damaged cells. Dysregulation of apoptosis can contribute to the pathogenesis of
Shengli Dong +2 more
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Journal of Applied Sciences and Environmental Management, 2018 Plant extracts are excellent alternatives as corrosion inhibitors because of availability, low toxicity, biodegradability and low cost. In this study, corrosion tests were performed on mild steel to evaluate the effect of concentration of inhibitor ...
G.A. Cookey, B.L. Tambari, D.S. Iboroma
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Development of a novel family of antifungal agents based on a quinone methide oxime framework
Scientific ReportsGiven the widespread occurrence of fungal infections, the phenomenon of fungal drug resistance, and the limited number of systemic antimycotic therapies, novel chemicals should be developed to control pathogenic fungi.
Monika Janeczko +14 more
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Jurnal Teknik MesinCorrosion is one of the main problems causing damage to metals. The occurrence of a reaction with the surrounding environment accompanied by several factors cause deterioration so that corrosion causes damage to the material. Therefore, researchers added
Miftachul Ulum, Afira Ainur Rosidah
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