Results 21 to 30 of about 2,020,141 (269)

DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies

Cells, 2023
DPP8/9 inhibition induces either pyroptotic or apoptotic cell death in hematological malignancies. We previously reported that treatment with the DPP8/9 inhibitor 1G244 resulted in apoptotic cell death in myeloma, and our current study further evaluates ...
Shohei Kikuchi, Akinori Wada, Yusuke Kamihara, Kosuke Okazaki, Paras Jawaid, Mati Ur Rehman, Eiji Kobayashi, Takeshi Susukida, Tomoki Minemura, Yoshimi Nabe, Noriaki Iwao, Tatsuhiko Ozawa, Ryo Hatano, Mitsugu Yamada, Hiroyuki Kishi, Yuji Matsuya, Mineyuki Mizuguchi, Yoshihiro Hayakawa, Nam H. Dang, Yasumitsu Sakamoto, Chikao Morimoto, Tsutomu Sato   +21 more
doaj   +1 more source

PEMANFAATAN EKSTRAK DAUN RAMBUTAN SEBAGAI INHIBITOR KOROSI PADA PLAT BESI DALAM MEDIA AIR PAYAU

Chemical Engineering Journal Storage, 2022
Abstrak Korosi adalah peristiwa kerusakan atau penurunan mutu suatu logam akibat reaksi elektrokimia dengan lingkungannya. Penanganan masalah korosi dapat dilakukan dengan menambahkan inhibitor korosi dari ekstrak daun rambutan yang mengandung tanin dan
Rizzki Andira, Zulnazri Zulnazri, Syamsul Bahri, Azhari Azhari, Agam Muarif   +4 more
doaj   +1 more source

Gibberellin: inhibitor of an inhibitor of...?

BioEssays, 1999
Gibberellin is an endogenous plant growth regulator. Here, we describe our present understanding of how gibberellin regulates plant growth, using recent results gained from studies of gibberellin-signalling mutants of Arabidopsis. These results show that a signalling pathway represses plant growth and that gibberellin releases this repression.
Harberd, N, King, K, Carol, P, Cowling, R, Peng, J, Richards, D   +5 more
openaire   +3 more sources

Identification of Modulators of HIV-1 Proviral Transcription from a Library of FDA-Approved Pharmaceuticals

Viruses, 2020
Human immunodeficiency virus 1 (HIV-1) is the most prevalent human retrovirus. Recent data show that 34 million people are living with HIV-1 worldwide.
Gavin C. Sampey, Sergey Iordanskiy, Michelle L. Pleet, Catherine DeMarino, Fabio Romerio, Renaud Mahieux, Fatah Kashanchi   +6 more
doaj   +1 more source

Caspase inhibitors [PDF]

Cell Death & Differentiation, 1999
Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
P G, Ekert, J, Silke, D L, Vaux
openaire   +2 more sources

Ekstrak Kulit Manggis (Garcinia Mangostana L) Sebagai Inhibitor Korosi Baja Lunak (Mild Steel) Dalam Larutan H2SO4 1 M

Teknika, 2014
Berdasarkan berbagai penelitian, kulit manggis memiliki potensi yang baik sebagai inhibitor korosi Tujuan dari penelitian ini adalah untuk mengetahui efisiensi ekstrak inhibitor kulit manggis pada baja lunak dalam larutan asam sulfat.
Marta Pramudita, Hendri Juliansyah, Muhammad Andre Rizki   +2 more
doaj   +1 more source

High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC inhibitors has attracted increasing ...
Mazen Aseeri, José Luis Abad, Antonio Delgado, Gemma Fabriàs, Gemma Triola, Josefina Casas   +5 more
doaj   +1 more source

Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Schistosoma mansoni is an intestinal parasite with one β-class carbonic anhydrase, SmaBCA. We report the sequence enhancing, production, catalytic activity, and inhibition results of the recombinant SmaBCA. It showed significant catalytic activity on CO2
Susanna Haapanen, Andrea Angeli, Martti Tolvanen, Reza Zolfaghari Emameh, Claudiu T. Supuran, Seppo Parkkila   +5 more
doaj   +1 more source

Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Structural tailoring of the flavone framework (position 7) via organopalladium-catalyzed C–C bond formation was attempted in this study. The impact of substituents with varied electronic effects (phenyl ring, position 2 of the benzopyran scaffold) on the
Sachin Sharma, Kavya Chandra, Aliva Naik, Anamika Sharma, Ram Sharma, Amandeep Thakur, Ajmer Singh Grewal, Ashwani K. Dhingra, Arnab Banerjee, Jing Ping Liou, Santosh Kumar Guru, Kunal Nepali   +11 more
doaj   +1 more source

Combined Activity of the Redox-Modulating Compound Setanaxib (GKT137831) with Cytotoxic Agents in the Killing of Acute Myeloid Leukemia Cells

Antioxidants, 2022
Acute myeloid leukemia (AML) cells harbor elevated levels of reactive oxygen species (ROS), which promote cell proliferation and cause oxidative stress. Therefore, the inhibition of ROS formation or elevation beyond a toxic level have been considered as ...
Muhammed Burak Demircan, Peter C. Mgbecheta, Anne Kresinsky, Tina M. Schnoeder, Katrin Schröder, Florian H. Heidel, Frank D. Böhmer   +6 more
doaj   +1 more source