Results 21 to 30 of about 3,476,202 (307)

The role and action mechanism of inhibitors in solutions for etching steel

open access: yesZaštita Materijala, 2015
Acid etching has a major task, regardless of which acid is used, to cancel all corrosion products from objects before it starts to erode base material.
Bosiljka Ljubičić, Saša Mićin
doaj   +1 more source

PARP inhibitors [PDF]

open access: yesHereditary Cancer in Clinical Practice, 2015
بوليميرازات بولي (ADP - ريبوز)، التي يتم اختصارها باسم PARPs، هي مجموعة من البروتينات المألوفة التي تلعب دورًا مركزيًا في إصلاح الحمض النووي باستخدام مسار إصلاح استئصال القاعدة (BER). هناك حوالي 17 بروتينًا في هذه العائلة منها PARPs النووية الأولية هي PARP -1 و PARP -2 و PARP -3 و tankyrases 1 و 2 (PARP -5a و -5b).
Maheen Anwar   +2 more
openaire   +2 more sources

Ekstrak Kulit Manggis (Garcinia Mangostana L) Sebagai Inhibitor Korosi Baja Lunak (Mild Steel) Dalam Larutan H2SO4 1 M

open access: yesTeknika, 2014
Berdasarkan berbagai penelitian, kulit manggis memiliki potensi yang baik sebagai inhibitor korosi Tujuan dari penelitian ini adalah untuk mengetahui efisiensi ekstrak inhibitor kulit manggis pada baja lunak dalam larutan asam sulfat.
Marta Pramudita   +2 more
doaj   +1 more source

High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2023
Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC inhibitors has attracted increasing ...
Mazen Aseeri   +5 more
doaj   +1 more source

The Effect of NAG–thiazoline on Morphology and Surface Hydrophobicity of Escherichia Coli [PDF]

open access: yes, 2004
The β-hexosaminidase inhibitor and structural analog of the putative oxazolium reaction intermediate of lytic transglycosylases, N-acetylglucosamine thiazoline (NAG–thiazoline), was synthesized in 46% overall yield and tested as an inhibitor of ...
Blackburn, Neil T.   +2 more
core   +2 more sources

Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2023
Schistosoma mansoni is an intestinal parasite with one β-class carbonic anhydrase, SmaBCA. We report the sequence enhancing, production, catalytic activity, and inhibition results of the recombinant SmaBCA. It showed significant catalytic activity on CO2
Susanna Haapanen   +5 more
doaj   +1 more source

Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2023
Structural tailoring of the flavone framework (position 7) via organopalladium-catalyzed C–C bond formation was attempted in this study. The impact of substituents with varied electronic effects (phenyl ring, position 2 of the benzopyran scaffold) on the
Sachin Sharma   +11 more
doaj   +1 more source

Combined Activity of the Redox-Modulating Compound Setanaxib (GKT137831) with Cytotoxic Agents in the Killing of Acute Myeloid Leukemia Cells

open access: yesAntioxidants, 2022
Acute myeloid leukemia (AML) cells harbor elevated levels of reactive oxygen species (ROS), which promote cell proliferation and cause oxidative stress. Therefore, the inhibition of ROS formation or elevation beyond a toxic level have been considered as ...
Muhammed Burak Demircan   +6 more
doaj   +1 more source

Farnesyltransferase inhibitors

open access: yesSeminars in Oncology, 2001
The targeting of molecular abnormalities in neoplasms may provide an opportunity to improve the selectivity of cancer therapy. Ras mutations are a common genetic event in human cancers. Other genetic changes in tumors can signal through ras-dependent pathways as well.
Hahn, S, Bernhard, E, Mckenna, W
openaire   +3 more sources

Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring. [PDF]

open access: yes, 2009
In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring is not generally available in resource-limited settings. We examined switching from
Boulle, A   +18 more
core   +4 more sources

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