Results 21 to 30 of about 2,029,248 (269)

Small molecule Mcl-1 inhibitor for triple negative breast cancer therapy

Frontiers in Cell and Developmental Biology
Apoptosis is an evolutionarily conserved cell death pathway that plays a crucial role in maintaining tissue homeostasis, orchestrating organismal development, and eliminating damaged cells. Dysregulation of apoptosis can contribute to the pathogenesis of
Shengli Dong, Suresh K. Alahari, Suresh K. Alahari   +2 more
doaj   +1 more source

Evaluation of the corrosion inhibition potentials of green-tip forest lily (Clivia nobilis) leaves extract on mild steel in acid media

Journal of Applied Sciences and Environmental Management, 2018
Plant extracts are excellent alternatives as corrosion inhibitors because of availability, low toxicity, biodegradability and low cost. In this study, corrosion tests were performed on mild steel to evaluate the effect of concentration of inhibitor ...
G.A. Cookey, B.L. Tambari, D.S. Iboroma
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Development of a novel family of antifungal agents based on a quinone methide oxime framework

Scientific Reports
Given the widespread occurrence of fungal infections, the phenomenon of fungal drug resistance, and the limited number of systemic antimycotic therapies, novel chemicals should be developed to control pathogenic fungi.
Monika Janeczko, Maciej Masłyk, Oleg M. Demchuk, Antonina Kurowska-Okoń, Mateusz Kwaśnik, Kamila Górka, Aleksandra Martyna, Béatrice Foll-Josselin, Sandrine Ruchaud, Stéphane Bach, Przemysław Woliński, Radomir Jasiński, Barbara Mirosław, Małgorzata Sadczuk, Konrad Kubiński   +14 more
doaj   +1 more source

The Effect of Paracetamol Inhibitor Concentration and Immersion Time to The Corrosion Rate and Toughness in 3% NaCl Media

Jurnal Teknik Mesin
Corrosion is one of the main problems causing damage to metals. The occurrence of a reaction with the surrounding environment accompanied by several factors cause deterioration so that corrosion causes damage to the material. Therefore, researchers added
Miftachul Ulum, Afira Ainur Rosidah
doaj   +1 more source

p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD [PDF]

Current Opinion in Pharmacology, 2012
COPD represents a major respiratory disorder, causing significant morbidity and mortality throughout the world. While therapies exist for COPD, they are not always effective, and many patients experience exacerbations and morbidity despite current therapies.
Audreesh, Banerjee, Cynthia, Koziol-White, Reynold, Panettieri   +2 more
openaire   +2 more sources

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Mechanism of secondary recrystallization of Goss grains in grain-oriented electrical steel

Science and Technology of Advanced Materials, 2017
Since its invention by Goss in 1934, grain-oriented (GO) electrical steel has been widely used as a core material in transformers. GO exhibits a grain size of over several millimeters attained by secondary recrystallization during high-temperature final ...
Yasuyuki Hayakawa
doaj   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source