Results 11 to 20 of about 2,020,141 (269)
Experimental study on inhibition of coal spontaneous combustion by hydroxyethylene diphosphonic acid
Meikuang Anquan, 2022 In order to study the effect of hydroxyethylene diphosphonic acid（HEDP） on the characteristics of coal spontaneous combustion, a temperature-programmed gas chromatography experiment was carried out to compare and analyze the production and development of
SUN Meng +3 more
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The selective inhibition of the Syk tyrosine kinase ameliorates experimental autoimmune arthritis
Frontiers in Immunology, 2023 Autoimmune arthritis – such as rheumatoid arthritis – affect a significant proportion of the population, which can cause everyday joint pain, decreased mobility and reduced quality of life.
Eszter Káposztás +11 more
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Electrochemistry, 2021 Electrochemical methods were used in conjunction with digital holography to study the effects of an environmentally friendly inhibitor, polyaspartic acid (PASP), on the anodic dissolution of Inconel® 600 in a 0.04 M HCl solution.
Yu SHAO +4 more
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p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD [PDF]
Current Opinion in Pharmacology, 2012 COPD represents a major respiratory disorder, causing significant morbidity and mortality throughout the world. While therapies exist for COPD, they are not always effective, and many patients experience exacerbations and morbidity despite current therapies.
Audreesh, Banerjee +2 more
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Discovery of novel spike/ACE2 inhibitory macrocycles using in silico reinforcement learning
Frontiers in Drug Discovery, 2022 Introduction: The COVID-19 pandemic has cast a heavy toll in human lives and global economics. COVID-19 is caused by the SARS-CoV-2 virus, which infects cells via its spike protein binding human ACE2.Methods: To discover potential inhibitory ...
Lev Shapira +9 more
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Frontiers in Chemistry, 2020 Cyclin-dependent kinases (CDKs) constitute a family of 20 serine/threonine protein kinases that play pivotal roles in the regulation of numerous important molecular and cellular processes. CDKs have long been considered promising therapeutic targets in a
Thomas Robert +8 more
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A novel autophagy inhibitor, bTBT, disturbs autophagosome formation
Autophagy Reports, 2023 Macroautophagy (hereafter, autophagy) is a form of intracellular degradation in which autophagosome formation is systematically coordinated by multiple processes involving numerous autophagy-related gene (ATG) proteins. Autophagy-modulating compounds are
Momoka Chiba +6 more
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Immuno-Oncology and Technology, 2023 Background: Autotaxin-lysophosphatidic acid (ATX-LPA) signaling has a predominant role in immunological and fibrotic processes, including cancer. Several ATX inhibitors and LPA receptor antagonists have been clinically evaluated, but none in patients ...
M.A. Deken +16 more
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Extracts from European Propolises as Potent Tyrosinase Inhibitors
Molecules, 2022 Tyrosinase is a key enzyme in the melanogenesis pathway. Melanin, the product of this process, is the main pigment of the human skin and a major protection factor against harmful ultraviolet radiation (UVR).
Jarosław Widelski +7 more
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Molecules, 2022 Cancer is a multifactorial disorder caused by several aberrations in gene expression that generate a homeostatic imbalance between cell division and death [...]
Alessandra Ammazzalorso +1 more
openaire +3 more sources