Results 31 to 40 of about 3,447,958 (308)

Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors

Molecules, 2023
Sulfonamides remain an important class of drugs, especially because of their inhibitory effects on carbonic anhydrases. Herein, we have synthesized several sulfonamides and tested them for their inhibitory activity against carbonic anhydrases hCA I, hCA ...
Toni C. Denner, Andrea Angeli, Marta Ferraroni, Claudiu T. Supuran, René Csuk   +4 more
doaj   +1 more source

Selective serotonin reuptake inhibitors in the treatment of generalized anxiety disorder [PDF]

, 2002
Selective serotonin reuptake inhibitors have proven efficacy in the treatment of panic disorder, obsessive–compulsive disorder, post-traumatic stress disorder and social anxiety disorder.
Allgulander C, Andrew Mayers, Ansseau M, Aufdembrinke B. Abercarnil,, Ballenger JC, Barlow DH, Beekman AT, Carter RM, Chamey DS, Christel Buis, Connor KM, David Baldwin, Davidson JR, Durham RC, Durham RC, ECNP Consensus meeting, March, Fairbanks JM, Fawcett J, Feighner JP, Field MJ, Fontaine R, Gammans RE, Gelenberg AJ, Goa KL, Goldberg HL, Gould RA, Gould RA, Hedges DW, Hurst M, Keller MB, Pollack MET, Power KG, Rickels K, Rocca P, Rocca P, Sevy S, Sitsen JMA, Sramek JJ, Stahl S, Wardle J, Weizman R, Wittchen HU   +41 more
core   +1 more source

In Vitro Antithrombotic, Hematological Toxicity, and Inhibitor Studies of Protocatechuic, Isovanillic, and p-Hydroxybenzoic Acids from Maclura tricuspidata (Carr.) Bur

Molecules, 2022
In blood coagulation, circulating platelets and coagulation factors are crucial for the primary process because thrombi are generated by fibrin clotting with fibrinogen, thrombin, FXIIIa, and platelet activation.
Jun-Hui Choi, Seung Kim
doaj   +1 more source

Suppressing nonsense--a surprising function for 5-azacytidine. [PDF]

, 2014
In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but ...
Shao, Ada, Wilkinson, Miles F
core   +2 more sources

Caspase inhibitors [PDF]

Cell Death & Differentiation, 1999
Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
P G, Ekert, J, Silke, D L, Vaux
openaire   +2 more sources

Anticancer Inhibitors

Molecules, 2022
Cancer is a multifactorial disorder caused by several aberrations in gene expression that generate a homeostatic imbalance between cell division and death [...]
Alessandra Ammazzalorso, Marialuigia Fantacuzzi   +1 more
openaire   +3 more sources

Development of a novel family of antifungal agents based on a quinone methide oxime framework

Scientific Reports
Given the widespread occurrence of fungal infections, the phenomenon of fungal drug resistance, and the limited number of systemic antimycotic therapies, novel chemicals should be developed to control pathogenic fungi.
Monika Janeczko, Maciej Masłyk, Oleg M. Demchuk, Antonina Kurowska-Okoń, Mateusz Kwaśnik, Kamila Górka, Aleksandra Martyna, Béatrice Foll-Josselin, Sandrine Ruchaud, Stéphane Bach, Przemysław Woliński, Radomir Jasiński, Barbara Mirosław, Małgorzata Sadczuk, Konrad Kubiński   +14 more
doaj   +1 more source

Small molecule Mcl-1 inhibitor for triple negative breast cancer therapy

Frontiers in Cell and Developmental Biology
Apoptosis is an evolutionarily conserved cell death pathway that plays a crucial role in maintaining tissue homeostasis, orchestrating organismal development, and eliminating damaged cells. Dysregulation of apoptosis can contribute to the pathogenesis of
Shengli Dong, Suresh K. Alahari, Suresh K. Alahari   +2 more
doaj   +1 more source

Selection of effective wax (deposition) inhibitors to oil production and transportation at the Kondinskoye oil field

Известия высших учебных заведений: Нефть и газ, 2020
The article discusses the results of a study on the selection of wax inhibitors that can be used at the Kondinskoye oil field during transportation and dehydration of the emulsion.Asphaltene precipitation is one of the most serious issues in oil ...
E. N. Skvortsova, O. P. Deryugina
doaj   +1 more source

Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring. [PDF]

, 2009
In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring is not generally available in resource-limited settings. We examined switching from
Boulle, A, Braitstein, P, Brinkhof, Martin, Calmy, A, Dabis, F, Egger, Matthias, Jahn, A, Keiser, O, Keiser, Olivia, Kumarasamy, N, Lüthy, R, MacPhail, P, Nash, D, Pujades-Rodriguez, M, Schechter, M, Sprinz, E, Tuboi, S, Tweya, H, Wood, R   +18 more
core   +4 more sources