Results 31 to 40 of about 7,182,372 (402)

Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]

, 2011
Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines, Carrillo Gil, Laura, Diaz Rodriguez, Isabel, Herrero, Ignacio, Martinez Muñoz, Manuel, Sánchez-Monge Laguna de Rins, Rosa   +5 more
core   +2 more sources

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels

Frontiers in Pharmacology, 2022
Vanilloid-subfamily TRP channels TRPV1-6 play important roles in various physiological processes and are implicated in numerous human diseases. Advances in structural biology, particularly the “resolution revolution” in cryo-EM, have led to breakthroughs
Maria V. Yelshanskaya, Alexander I. Sobolevsky   +1 more
doaj   +1 more source

Kinetic and thermodynamic analysis of leech-derived tryptase inhibitor interaction with bovine tryptase and bovine trypsin [PDF]

, 2000
The interaction of leech-derived tryptase inhibitor (LDTI) with bovine liver capsule tryptase (BLCT) and bovine trypsin has been studied using both thermodynamic and kinetic approaches.
Auerswald E.A., Cromlish J.A., Fiorucci L., Fiorucci L., Harvima I.T., Smith T.J., Sommerhoff C.P.   +6 more
core   +1 more source

Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase

Frontiers in Chemistry, 2022
A new series of flexible 5′-norcarbocyclic aza/deaza-purine nucleoside analogs were synthesized from 6-oxybicyclo[3.1.0.]hex-2-ene and pyrazole-containing fleximer analogs of heterocyclic bases using the Trost procedure.
Anastasia Khandazhinskaya, Ilja Fateev, Irina Konstantinova, Roman Esipov, Konstantin Polyakov, Katherine Seley-Radtke, Sergey Kochetkov, Elena Matyugina   +7 more
doaj   +1 more source

Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs

JAMA Network Open, 2019
Key Points Question What is the estimated percentage of US patients with cancer who are eligible for and respond to checkpoint inhibitor drugs approved for oncology indications by the US Food and Drug Administration?
A. Haslam, V. Prasad
semanticscholar   +1 more source

Farnesyltransferase inhibitors

Seminars in Oncology, 2001
The targeting of molecular abnormalities in neoplasms may provide an opportunity to improve the selectivity of cancer therapy. Ras mutations are a common genetic event in human cancers. Other genetic changes in tumors can signal through ras-dependent pathways as well.
Hahn, S, Bernhard, E, Mckenna, W
openaire   +3 more sources

C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation

mBio, 2022
Acinetobacter baumannii has become a major nosocomial pathogen, as it is often multidrug-resistant, which results in infections characterized by high mortality rates. The bacterium achieves high levels of resistance to β-lactam antibiotics by producing β-
Nichole K. Stewart, Marta Toth, Maha A. Alqurafi, Weirui Chai, Thu Q. Nguyen, Pojun Quan, Mijoon Lee, John D. Buynak, Clyde A. Smith, Sergei B. Vakulenko   +9 more
doaj   +1 more source

In vivo E2F reporting reveals efficacious schedules of MEK1/2–CDK4/6 targeting and mTOR–s6 resistance mechanisms [PDF]

, 2018
Targeting cyclin-dependent kinases 4/6 (CDK4/6) represents a therapeutic option in combination with BRAF inhibitor and/or MEK inhibitor (MEKi) in melanoma; however, continuous dosing elicits toxicities in patients. Using quantitative and temporal in vivo
Aplin, Andrew E., Cheng, Phil F., Chervoneva, Inna, Davies, Michael A., Dummer, Reinhard, Ertel, Adam, Fortina, Paolo, Hookim, Kim, Kleiber, Ines, Kwong, Lawrence N., Levesque, Mitch P., Nikbakht, Neda, Patel, Prem, Purwin, Timothy J., Teh, Jessica L. F.   +14 more
core   +1 more source

Transcription and Translation Inhibitors in Cancer Treatment

Frontiers in Chemistry, 2020
Transcription and translation are fundamental cellular processes that govern the protein production of cells. These processes are generally up regulated in cancer cells, to maintain the enhanced metabolism and proliferative state of these cells.
Nihay Laham-Karam, Gaspar P. Pinto, Gaspar P. Pinto, Antti Poso, Antti Poso, Piia Kokkonen   +5 more
doaj   +1 more source

Improving the Efficiency of Oil and Gas Wells Complicated by the Formation of Asphalt–Resin–Paraffin Deposits

Energies, 2021
A number of difficulties may be encountered in the final stages of oil field exploitation, including the formation of asphalt–resin–paraffin deposits (ARPDs).
Karina Shamilyevna Nurgalieva, Liliya Albertovna Saychenko, Masoud Riazi   +2 more
doaj   +1 more source