The regulation of inhibitor of apoptosis proteins (IAPs) during the apoptosis of Cotesia chilonis [PDF]
Frontiers in Physiology, 2023 Inhibitor of apoptosis proteins (IAPs) are crucial components of apoptosis that perform vital roles in the regulation of caspase activity in organisms.
Ming-Xing Lu +4 more
doaj +4 more sources
Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer [PDF]
Frontiers in Oncology, 2023 Evasion from apoptosis is a hallmark of cancer. Inhibitor of apoptosis proteins (IAPs) contribute to this hallmark by suppressing the induction of cell death.
Philipp Wolf, Philipp Wolf
doaj +2 more sources
Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins [PDF]
Cell Death and Disease, 2023 Bruton’s tyrosine kinase inhibitors (BTKi) and CAR T-cell therapy have demonstrated tremendous clinical benefits in mantle cell lymphoma (MCL) patients, but intrinsic or acquired resistance inevitably develops.
Yijing Li +15 more
doaj +2 more sources
Recent advances in understanding inhibitor of apoptosis proteins. [PDF]
F1000Res, 2018 The inhibitor of apoptosis proteins (IAPs) are a family of proteins that were chiefly known for their ability to inhibit apoptosis by blocking caspase activation or activity. Recent research has shown that cellular IAP1 (cIAP1), cIAP2, and X-linked IAP (XIAP) also regulate signaling by receptors of the innate immune system by ubiquitylating their ...
Lalaoui N, Vaux DL.
europepmc +5 more sources
Inhibitor of apoptosis proteins as intracellular signaling intermediates. [PDF]
FEBS J, 2016 Inhibitor of apoptosis (IAP) proteins have often been considered inhibitors of cell death due to early reports that described their ability to directly bind and inhibit caspases, the primary factors that implement apoptosis. However, a greater understanding is evolving regarding the vital roles played by IAPs as transduction intermediates in a diverse ...
Kocab AJ, Duckett CS.
europepmc +4 more sources
Inhibitor of Apoptosis (IAP) proteins in pediatric leukemia: Molecular pathways and novel approaches to therapy [PDF]
Frontiers in Oncology, 2014 Inhibitor of Apoptosis (IAP) proteins are a family of proteins with antiapoptotic functions that contribute to the evasion of apoptosis, a form of programmed cell death.
Simone eFulda
doaj +2 more sources
Anti-apoptotic signaling as a cytoprotective mechanism in mammalian hibernation [PDF]
PeerJ, 2013 In the context of normal cell turnover, apoptosis is a natural phenomenon involved in making essential life and death decisions. Apoptotic pathways balance signals which promote cell death (pro-apoptotic pathways) or counteract these signals (anti ...
Andrew N. Rouble +4 more
doaj +2 more sources
Di-san junyi daxue xuebao, 2022 Objective To explore the molecular mechanism of tetrandrine sensitizing vincristine to induce apoptosis of gastric cancer SGC-7901/VCR cells. Methods SGC-7901/VCR cells were treated with tetrandrine (0, 2, 4, 6 and 8 μmol/L) and vincristine (0, 50, 100 ...
LEI Ling +5 more
doaj +1 more source
Inhibitor of apoptosis proteins and apoptosis [PDF]
Acta Biochimica et Biophysica Sinica, 2008 Apoptosis is a physiological cell death process that plays a critical role in development, homeostasis, and immune defense of multicellular animals. Inhibitor of apoptosis proteins (IAPs) constitute a family of proteins that possess between one and three baculovirus IAP repeats.
Yunbo, Wei, Tingjun, Fan, Miaomiao, Yu
openaire +2 more sources
Metformin inhibits the apoptosis of intervertebral disc tissue cells in rabbit model with lumbar intervertebral disc degeneration [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the impacts of metformin on autophagy and inflammation of intervertebral disc tissue in rabbits, so as to preliminarily explore the molecular mechanism of its anti-intervertebral disc degeneration.
DONG Junli, CAI Shaokang, YAN Lei, CAI Yi
doaj +1 more source