Application of Western Blot for detection of neutrophil apoptosis-related proteins
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2009 The aim of this study was to evaluate suitability of using Western Blot for detection of neutrophil apoptosis and neutrophil apoptosis-related proteins, respectively. Neutrophils were isolated from blood of healthy adult donors and incubated with G-CSF
Petr Sláma
doaj +1 more source
Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs [PDF]
, 2018 Rocaglamide has been reported to sensitize several cell types to TRAIL-induced apoptosis. In recent years, advances in synthetic techniques have led to generation of novel rocaglamide analogs.
Brown, Lauren E. +5 more
core +2 more sources
Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-κB activation [PDF]
, 2013 Kaposi's sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein K13
Ahmad +53 more
core +1 more source
Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. [PDF]
, 2020 Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced ...
Chen, Wei-Rong +8 more
core
The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]
, 2007 Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Albert JM +35 more
core +1 more source
Targeting Inhibitor of Apoptosis Proteins to Overcome Chemotherapy Resistance-A Marriage between Targeted Therapy and Cytotoxic Chemotherapy. [PDF]
Int J Mol Sci, 2023 Barroso T +4 more
europepmc +1 more source
Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment
Computational and Structural Biotechnology Journal, 2019 Inhibitor of apoptosis (IAP) proteins are characterized by the presence of the conserved baculoviral IAP repeat (BIR) domain that is involved in protein-protein interactions.
Federica Cossu +3 more
doaj +1 more source
Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins. [PDF]
J Med Chem, 2023 Ng YLD +9 more
europepmc +1 more source
Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]
, 2012 The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A +7 more
core +1 more source
Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP
Molecular & Cellular Oncology, 2018 ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis).
Dana Mamriev, Sarit Larisch
doaj +1 more source