Results 101 to 110 of about 765,759 (204)

Radio-Sensitization of Human Leukaemic MOLT-4 Cells by DNA-Dependent Protein Kinase Inhibitor, NU7026

Acta Medica, 2012
In this paper we describe the influence of NU7026, a specific inhibitor of DNA-dependent protein kinase, phosphoinositide 3-kinase, and ATM-kinase on molecular and cellular mechanisms triggered by ionising irradiation in human T-lymphocyte leukaemic MOLT-
Aleš Tichý, Eva Novotná, Kamila Ďurišová, Barbora Šalovská, Radka Sedlaříková, Jaroslav Pejchal, Lenka Zárybnická, Jiřina Vávrová, Zuzana Šinkorová, Martina Řezáčová   +9 more
doaj   +1 more source

Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer-A Promising Signaling Network for Therapeutic Interventions. [PDF]

Cancers (Basel), 2021
Güllülü Ö, Hehlgans S, Rödel C, Fokas E, Rödel F.   +4 more
europepmc   +1 more source

Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins

Oncology Letters, 2016
In the present study, we investigated the effects and mechanisms of Osthole on the apoptosis of non-small cell lung cancer (NSCLC) cells and its synergistic effect with Embelin. Our results revealed that treatment with both Osthole and Embelin inhibited cell proliferation.
Xu, Xiao-Man, Zhang, Man-Li, Zhang, Yi, Zhao, Li   +3 more
openaire   +3 more sources

Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models. [PDF]

Cell Death Dis, 2021
Clark MP, Huynh T, Rao S, Mackiewicz L, Mason H, Romal S, Stutz MD, Ahn SH, Earnest L, Sozzi V, Littlejohn M, Tran BM, Wiedemann N, Vincan E, Torresi J, Netter HJ, Mahmoudi T, Revill P, Pellegrini M, Ebert G.   +19 more
europepmc   +1 more source

Killing HIV-infected resting central memory CD4⁺ T cells by targeting inhibitor of apoptosis proteins-inhibited autophagy. [PDF]

Antivir Chem Chemother, 2021
Zhang G, Huang X.
europepmc   +1 more source

Role of EZH2 Inhibitor Combined with Gefitinib in EGFR-TKIs Resistant Lung Cancer Cells

Chinese Journal of Lung Cancer, 2019
Background and objective Lung cancer is one of the common malignant tumors that impair human health. With the development of epigenetics, the researchers found that enhancer of Zeste homolog 2 (EZH2) is highly expressed in lung cancer tissue and its ...
Hao GONG, Yin YUAN, Yongwen LI, Hongbing ZHANG, Ying LI, Weiting LI, Pan WANG, Ruifeng SHI, Chao LIU, Liyuan CUI, Hongyu LIU, Jun CHEN   +11 more
doaj   +1 more source

Sulforaphane Protects Against Ethanol-Induced Apoptosis in Human Neural Crest Cells Through Diminishing Ethanol-Induced Hypermethylation at the Promoters of the Genes Encoding the Inhibitor of Apoptosis Proteins. [PDF]

Front Cell Dev Biol, 2021
Li Y, Fan H, Yuan F, Lu L, Liu J, Feng W, Zhang HG, Chen SY.   +7 more
europepmc   +1 more source

A preexisting rare PIK3CA e545k subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling [PDF]

, 2018
Combined MEK and CDK4/6 inhibition (MEKi + CDK4i) has shown promising clinical outcomes in patients with NRAS- mutant melanoma. Here, we interrogated longitudinal biopsies from a patient who initially responded to MEKi + CDK4i therapy but subsequently ...
Amaria, Rodabe N., Aplin, Andrew A., Carapeto, Fernando C.L., Chen, Merry, Chen, Pei-Ling, Davies, Michael A., Duose, Dzifa Y., Futreal, P. Andrew, Kwong, Lawrence N., Lazar, Alexander J., Li, Jun, Liang, Roger J., Liu, Mingguang, McQuade, Jennifer L., Roh, Whijae, Romano, Gabriele, Song, Ping, Teh, Jessica L.F., Wargo, Jennifer A., Zhang, David Y., Zhang, Jianhua   +20 more
core   +1 more source

Expression of livin protein in lung cancer and its relation with the expression of pro-caspase3 protein

Chinese Journal of Lung Cancer, 2008
Background and objective Livin is a novel inhibitor of apoptosis protein (IAP), recent studies showed it overexpresses in a variety of carcinomas including lung cancer and contributes much to the cancerous development.
Hongru LI, Yusheng CHEN, Gang CHEN, Baosong XIE, Lifang LIN   +4 more
doaj  

Molecular and Functional Characterization of Inhibitor of Apoptosis Proteins (IAP, BIRP) in Echinococcus granulosus. [PDF]

Front Microbiol, 2020
Zhan J, Song H, Wang N, Guo C, Shen N, Hua R, Shi Y, Angel C, Gu X, Xie Y, Lai W, Peng X, Yang G.   +12 more
europepmc   +1 more source