Results 111 to 120 of about 765,759 (204)

The role of DRP1 mediated mitophagy in HT22 cells apoptosis induced by silica nanoparticles

Ecotoxicology and Environmental Safety
Silica nanoparticles (SiNPs) are widely used in the biomedical field and can enter the central nervous system through the blood-brain barrier, causing damage to hippocampal neurons. However, the specific mechanism remains unclear.
Tiantian Tian, Huan Pang, Xinyue Li, Kai Ma, Tianxiang Liu, Jiali Li, Zhixuan Luo, Meng Li, Qiaohong Hou, Huifang Hao, Jianfei Dong, Haiying Du, Xiaomei Liu, Zhiwei Sun, Chao Zhao, Xiuling Song, Minghua Jin   +16 more
doaj   +1 more source

XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. [PDF]

, 2018
Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single ...
Baek, Han Bit, Fernandez-Rubio, Aleida, Gandour-Edwards, Regina, Ghosh, Paramita M, Landesman, Yosef, Libertini, Stephen J, Lombard, Alan P, Mudryj, Maria, Nakagawa, Rachel, Nishida, Kristine, Siddiqui, Salma, Vidallo, Kathleen, Vinall, Ruth, Weiss, Robert H, Wettersten, Hiromi   +14 more
core   +1 more source

A Trichinella spiralis serine protease triggers gut epithelial apoptosis and destroys the barrier integrity to mediate larval invasion.

PLoS Neglected Tropical Diseases
BackgroundLarval invasion of gut mucosa is a crucial procedure in Trichinella spiralis infection. Previous studies showed that T. spiralis excretory-secretory proteins (ESP) disrupted gut epithelial integrity and promoted larval invasion by inducing ...
Qi Qi Lu, Xin Zhuo Zhang, Pei Kun Cong, Jin Yi Wu, Tian Ran Gao, Shao Rong Long, Ruo Dan Liu, Zhong Quan Wang, Jing Cui   +8 more
doaj   +1 more source

TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis. [PDF]

, 2019
TNFα-related apoptosis-inducing ligand (TRAIL), specifically initiates programmed cell death, but often fails to eradicate all cells, making it an ineffective therapy for cancer.
Baskar, Reema, Bendall, Sean C, Favaro, Patricia, Fienberg, Harris G, Green, Douglas R, Khair, Zumana, Kimmey, Sam, Nolan, Garry P, Plevritis, Sylvia   +8 more
core  

Molecular and cellular effects of the combined treatment with Camptothecin and Roscovitine in human lung and colon adenocarcinoma cells [PDF]

, 2008
De Mattia, Roberta
core   +1 more source

The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice. [PDF]

PLoS One, 2020
Bobardt M, Kuo J, Chatterji U, Wiedemann N, Vuagniaux G, Gallay P.   +5 more
europepmc   +1 more source

Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL [PDF]

, 2008
Adrian C. Newland, Aguilar-Santelises, Beckwith, Bosanquet, Breitschopf, Brooks, Chang, Chitambar, Chresta, Ciechanover, Clohessy, Dewson, Dohmen, Fandy, Fecker, Feng-Ting Liu, Hao, Hao, Hideshima, Hongtao Ye, Hsu, Inoue, Jia, Jia, Jia, John G. Gribben, Johnson, Kabore, Kelley, Kluin-Nelemans, Kuroda, Lashinger, Li, Li Jia, Liu, Liu, Lotan, Lundqvist, MacFarlane, McConkey, Ming-Qing Du, Mitsiades, Miyashita, Nikrad, Nishii, Pahler, Perez-Galan, Pigneux, Qin, Rudner, Samir G. Agrawal, Saxena, Sayers, Scheffner, Schmitt, Schwartz, Shah, Smolewski, Strauss, Sutheesophon, Upton, Willis   +61 more
core   +1 more source

Inhibitor of apoptosis proteins in breast cancer [PDF]

Breast Cancer Research, 2006
Foster, FM, Streuli, CH
openaire   +1 more source

Inhibitor of apoptosis proteins are potential targets for treatment of granulosa cell tumors - implications from studies in KGN. [PDF]

J Ovarian Res, 2019
Bagnjuk K, Kast VJ, Tiefenbacher A, Kaseder M, Yanase T, Burges A, Kunz L, Mayr D, Mayerhofer A.   +8 more
europepmc   +1 more source

Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes. [PDF]

Cell Death Dis, 2018
Gradzka S, Thomas OS, Kretz O, Haimovici A, Vasilikos L, Wong WW, Häcker G, Gentle IE.   +7 more
europepmc   +1 more source